Sökning: "O-sulfotransferase"

Hittade 5 avhandlingar innehållade ordet O-sulfotransferase.

  1. 1. In Vitro Studies of the Substrate Specificities of Heparan Sulfate 2-O- and 6-O-sulfotransferases

    Författare :Emanuel Smeds; Marion Kusche-Gullberg; Ulf Lindahl; Catherine L. R. Merry; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; heparin; sulfotransferase; 2-O-sulfotransferase; 6-O-sulfotransferase; polysaccharide biosynthesis; glycosaminoglycan; O-sulfotransferase; proteoglycan; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Heparan sulfate (HS), a linear negatively charged polysaccharide located at the cell surface and in the extracellular matrix, interacts with, and thereby regulates the functions of numerous proteins. HS-protein interactions depend on the fine structure of HS, especially its sulfation pattern. LÄS MER

  3. 2. Biosynthesis of Dermatan Sulphate. Enzymatic mechanism and role of cytokines

    Författare :Kerstin Tiedemann; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dermatan sulphate; 4-O-sulfotransferase; Co-polymeric structure; biglycan; decorin; Biochemistry; Biokemi; C5-epimerase; Metabolism;

    Sammanfattning : Dermatan sulphate is a prominent feature of several different proteoglycans and occurs in almost every tissue of the body. It is an unbranched polymer containing the repeating disaccharide unit of N-acetylgalactosamine and D-glucuronic acid or L-iduronic acid. LÄS MER

  4. 3. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

    Författare :Zuzanna Kurowska; Neural plasticitet och reparation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

    Sammanfattning : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. LÄS MER

  5. 4. Formation of Iduronic Acid during Chondroitin/Dermatan Sulfate Biosynthesis

    Författare :Emil Tykesson; Lungbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GLYCOSAMINOGLYCAN; CHONDROITIN; DERMATAN; EPIMERASE; SULFOTRANSFERASE; GLYCOSAMINOGLYCAN; CHONDROITIN SULFATE; DERMATAN SULFATE; EPIMERASE; SULFOTRANSFERASE;

    Sammanfattning : All animals and some bacteria can synthesize linear polysaccharides with a backbone of repeating disaccharideunits, called glycosaminoglycans (GAGs). The GAGs are either attached to a protein core, as in proteoglycans (PGs), or exist as free polymer chains, as in hyaluronan. LÄS MER

  7. 5. Understanding Heparan Sulfate Biosynthesis and Functional Implications of Heparanase

    Författare :Tianyi Song; Dorothe Spillmann; Cathrine Merry; Uppsala universitet; []
    Nyckelord :Heparan sulfate; biosynthesis; heparanase; lipid metabolism; cancer; cell adhesion; apoptosis.; Molekylär medicin;

    Sammanfattning : Heparan sulfate (HS) proteoglycans are present on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Heparanase is an endo-ß-glucuronidase that cleaves HS chains at internally located ß-glucuronidic linkages1. LÄS MER