Sökning: "Norovirus VA387"
Hittade 5 avhandlingar innehållade orden Norovirus VA387.
1. Computational Prediction and Analysis of Protein-Carbohydrate and Protein-Protein Interactions
Sammanfattning : The structure and energetics of protein-carbohydrate and protein-protein interactions are of great interest due to their importance in many biological phenomena. Two cases of protein-carbohydrate interactions and one case of protein-protein interactions were predicted and analyzed using existing computational methods. LÄS MER
2. Computational analysis of oligosaccharide conformations – methodological development, applied studies, and design of glycomimetics
Sammanfattning : Carbohydrates are the most abundant class of biomolecules. Besides their roles as structural elements and energy storage, they are involved in signaling and recognition processes. Their functions and activities depend on their preferred conformations. LÄS MER
3. Studies on interactions of norovirus capsid protein with fucosylated glycans and galactosylceramide as soluble and membrane bound ligands
Sammanfattning : Noroviruses (NVs) are among the most common viral pathogens which target the gastrointestinal (GI) tract and cause severe diarrhea, vomiting and episodes of abdominal cramps with fever. Millions of people around the world get infected with NVs annually, of which 200,000 cases are estimated to be fatal. LÄS MER
4. Application and Development of Computational Methods for Structure-based Drug Discovery
Sammanfattning : Researchers involved in drug discovery need tools to support their decisions regarding which of many available chemical entities could be developed into potent drug candidates. The qualitative and quantitative results from computational docking methods constitute the basis for structure-based rational design of inhibitors in the early stages of drug discovery. LÄS MER
5. Computer-Assisted Carbohydrate Structural Studies and Drug Discovery
Sammanfattning : Carbohydrates are abundant in nature and have functions ranging from energy storage to acting as structural components. Analysis of carbohydrate structures is important and can be used for, for instance, clinical diagnosis of diseases as well as in bacterial studies. The complexity of glycans makes it difficult to determine their structures. LÄS MER