Sökning: "Ncf1"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet Ncf1.

  1. 1. The Role of Reactive Oxygen Species in Animal Models of Autoimmunity

    Författare :Malin Hultqvist; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mice; Phytol; ROS; NOX; NADPH; p47phox; Ncf1; EAE; inflammation; Arthritis; RA; MS; Rats; Autoimmunity;

    Sammanfattning : Reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase complex are important in the killing of invading pathogens. Lately, a role of ROS has been suggested in regulation of the immune system. LÄS MER

  3. 2. Identification of Arthritis Regulating Genes in Rats

    Författare :Peter Olofsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; transplantation; Clinical genetics; Klinisk genetik; serology; Immunology; QTL; RA; Epistasis; Ncf1; Linkage; PIA; Arthritis; Rat;

    Sammanfattning : The immune response is designed to protect the body from harmful microbial invasions. However, when the immune system attacks itself instead, an autoimmune reaction starts that damage our own cells, tissues and organs. LÄS MER

  4. 3. Oxidative regulation of NCF1 in B cells and mouse models of arthritis

    Författare :Ana do Carmo Oliveira Coelho; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases (ADs) are chronic pathologies that result from a dysregulation of autoreactive B and T cells leading to autoantibody production and ultimately destruction of self. In paper I, we studied inflammation associated with autoimmunity. LÄS MER

  5. 4. Reduced ROS production triggers arthritis / The role of T cells in arthritis pathogenesis

    Författare :Jens Holmberg; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Spleen and lymph nodes Inflammation Reactive oxygen species T cells MHC; serology; Immunology; Immunologi; serologi;

    Sammanfattning : The aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. LÄS MER

  7. 5. The role of macrophages in regulating inflammation by oxidative burst

    Författare :Angela Pizzolla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The production of reactive oxygen species (ROS) through a process called oxidative burst is an essential defence mechanism against pathogens. In phagocytes, such as neutrophils and macrophages, the NADPH oxidase 2 (NOX2) complex is the main source of ROS. LÄS MER