Sökning: "Natalie Landeck"

Hittade 1 avhandling innehållade orden Natalie Landeck.

1. 1. Pathogenic effects of alpha-synuclein: modifications and toxicity

   Författare :Natalie Landeck; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :Parkinson s disease; adeno-associated viral vector; animal models; alpha-synuclein; substantia nigra; dopaminergic neurons; phosphorylation; aggregation; toxicity;

   Sammanfattning : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. LÄS MER