Sökning: "NSP4"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet NSP4.

  1. 1. Folding and retention of rotavirus glycoproteins in the endoplasmic reticulum

    Författare :Ali Mirazimi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ER; rotavirus; VP7; NSP4; oligosaccharide processing; N-linked glycosylation; protein disulfide isomerase; calnexin; ATP; ER retention;

    Sammanfattning : The endoplasmic reticulum (ER) is a membrane bound organelle composed of a network of cisternae stretching throughout the cytoplasm. Functionally, the ER performs many essential processes, such as glycosylation, and biosynthesis of lipids; it provides a redox potential condition for forming S-S linkages, and a quality control system, and functions as an intracellular calcium store. LÄS MER

  3. 2. Perturbation of the epithelial barrier by enteric pathogens

    Författare :Farideh Tafazoli; Magnusson Karl-Eric; Hakon Leffler; Linköpings universitet; []
    Nyckelord :enteric pathogens: signal transduction; barrier function; MEDICINE; MEDICIN;

    Sammanfattning : Gastrointestinal infections in humans have been associated with a number of diseased condition, including stomach ulcers, gastroenteritis, Crohn's disease, and rheumatic arthritis. Such infections often cause altered intestinal permeability through perturbation of the tight junctions that hold epithelial cells together. LÄS MER

  4. 3. Immune responses related to protection against rotavirus after natural infection and vaccination

    Författare :Kari Johansen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rotavirus is the most important cause of severe gastroenteritis in children under five years of age and is estimated to be responsible for one-third of all diarrhea-associated hospitalizations and 600,000 deaths/ year worldwide. 1500-1700 rotavirus-associated hospitalizations of children are estimated to occur annually in Sweden (3. LÄS MER

  5. 4. Rotavirus Disease Mechanisms Diarrhea, Vomiting and Inflammation : How and Why

    Författare :Marie Hagbom; Lennart Svensson; Karl-Eric Mangusson; Ove Lundgren; Niklas Arnberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Rotavirus infections cause diarrhea and vomiting that can lead to severe dehydration. Despite extensive tissue damage and cell death, the inflammatory response is very limited. LÄS MER

  7. 5. Macromolecular organization of the chikungunya virus replication organelle

    Författare :Timothée Laurent; Lars-Anders Carlson; Richard Lundmark; Alex Evilevitch; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The chikungunya virus is a positive-sense RNA virus responsible for the crippling chikungunya fever. It is transmitted through the bites of two species of mosquitoes: Aedes aegypti and Aedes albopictus. LÄS MER