Sökning: "NK cell-based therapy"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden NK cell-based therapy.

1. 1. Strategies to optimize T cell-based cancer immunotherapy

   Författare :Simona Vertuani; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MHC class 1; CTL; DNA vaccine; HER-2; Retinoic acid;

   Sammanfattning : Remarkable progress has been made in the field of tumor immunology in the past decade but active immunotherapy is not yet an established treatment modality. Tumor associated antigens (TAAs) presented in the form of peptides in association with MHC class 1 can be recognized by T cells and represent major targets of immunotherapy strategies to treat cancer patients. LÄS MER

3. 2. Natural killer cell development and function in the context of allogenic stem cell transplantation and cell therapy

   Författare :Alvaro Haroun-Izquierdo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Natural killer (NK) cells play a crucial role in the control of viral infections and transformed, cancerous cells. These innate cells have high cytotoxic capacities and use a multitude of receptors to interact with neighbouring cells. LÄS MER

4. 3. Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer

   Författare :Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes and loss of function mutations in tumor suppressor genes. LÄS MER

5. 4. Immunological recognition and tumor escape mechanisms of ovarian carcinoma

   Författare :Håkan Norell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Tumor immunology; Immune escape; Antitumor immunity; Ovarian carcinoma; NK cells; HLA class 1; LOH; IFN-γ; CTL; HLA-G; HLA-E; Activating receptors; NK cell-based therapy;

   Sammanfattning : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. LÄS MER

7. 5. The destiny of natural killer cells in the tumor microenvironment : to be suppressed or activated?

   Författare :Dhifaf Sarhan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In the mid-70s, the term “natural” was used based on the functional properties of NK cells where they recognize and lyse certain tumor cells without requirement of prior immunization. Although NK cells are “natural” in their targeting of tumors, their responses in the tumor microenvironment have been very challenging to determine. LÄS MER