Sökning: "Mutagenesis"

Visar resultat 1 - 5 av 295 avhandlingar innehållade ordet Mutagenesis.

  1. 1. Mutagenesis in wheat: An approach to make saline green!

    Författare :Johanna Lethin; Göteborgs universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Wheat; Mutagenesis; Salinity;

    Sammanfattning : The raising salinity in the soils around the world have been widely studied during the last decades due to the massive loss in agricultural land. Today, nearly 8% of the world’s arable land can no longer be used for crop cultivation due to salt contaminations, and more than half of the countries in the world are affected. LÄS MER

  3. 2. Characterization of galanin receptors using chimeric peptides and site-directed mutagenesis

    Författare :Ulla Eriksson Sollenberg; Ülo Langel; Anna-Lena Hulting; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galanin; GPCR; mutagenesis; neuropeptide; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Sammanfattning : Galanin, a 29 (30) amino acid neuropeptide, is found throughout both the central and peripheral nervous systems. It signals via three receptors, GalR1-3, all belonging to the rhodopsin-like G-protein coupled receptors. Galanin and its receptors have been implicated in a vast variety of biological processes. LÄS MER

  4. 3. Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

    Författare :Olof Modén; Bengt Mannervik; Mikael Widersten; Kenneth Tew; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; allelic variants; azathioprine; bioactivation; chimeric mutagenesis; directed evolution; DNA shuffling; enzyme engineering; glutathione transferase; GST; lysate screening; molecular docking; multiple alignment; multivariate analysis; polymorphism; principal component analysis; prodrug; prodrug activation; protein engineering; protein redesign; reduced amino acid alphabet; saturation mutagenesis; semi-rational enzyme engineering; site-directed mutagenesis; structure-activity relationship; structure-based redesign; Biokemi; Biochemistry;

    Sammanfattning : Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. LÄS MER

  5. 4. Receptor-ligand interactions of the human 5-HT1B receptor : A site-directed mutagenesis study

    Författare :Charlotta Grånäs; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; 5-hydroxytryptamine; serotonin; 5-HT1B receptor; site-directed mutagenesis; signal transduction; sumatriptan; G protein; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : The 5-hydroxytryptamine (5-HT, serotonin)1B receptor is one of thirteen G protein-coupled 5-HT receptors. 5-HT is known to influence temperature regulation, pain, cognition and sexual and feeding behaviours. LÄS MER

  7. 5. Mutagenesis induced by xenobiotics : factors of importance and modification, with special emphasis on glutathione and glutathione transferases

    Författare :Lennart Romert; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; genetik;

    Sammanfattning : Genetic changes induced by chemical agents can result in cancer. Such tumor formation can be linked to activationof oncogenes, often through specific, definable mutagenic events, e.g., single base-pair mutation in specific codons. LÄS MER