Sökning: "Multivalence"

Hittade 3 avhandlingar innehållade ordet Multivalence.

  1. 1. Synthetic Galectin Inhibitors Selective O-galactosyl aldoximes, multivalent lactosides and galactose-mimicking mannosides

    Författare :Johan Tejler; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteiner; enzymology; Proteins; Glycomimetic; Fragment based; Cluster effect; Multivalence; Triazole; Inhibitor; Aldoxime; enzymologi; Organic chemistry; Organisk kemi; Galectin; Lectin;

    Sammanfattning : This thesis describes the design, synthesis and evaluation of synthetic inhibitors for the carbohydrate binding proteins called galectins. Potent and selective inhibitors can be used as important research tools in the endeavor to chart the true role of galectins in biological events such as cancer and inflammation and possibly as lead for future galectin targeting drugs. LÄS MER

  3. 2. Human T-lymphocyte activation : interactions between lymphocytes and mitogenic or non-mitogenic lectins

    Författare :Marie-Louise Dillner-Centerlind; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The aim of this investigation was to gain further insights in the mechanisms of T-lymphocyte activation by lectins. Interactions between the lectins and purified lymphocytes from human peripheral blood, were studied in the following respects: in vitro culture requirements for lectin induced DNA-synthesis, intercellular regulations of the mitogen response and binding of lectins to lymphocyte surface components. LÄS MER

  4. 3. The Effect of Ladle Treatment on Steel Cleanness in Tool Steels

    Författare :Karin Steneholm; Pär Jönsson; Guozhu Ye; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; oxygen activity; inclusion characteristics; vacuum degassing; desulphurization; slag; ladle; hydrogen; nitrogen; deslagging; Teknisk materialvetenskap; Materials Science and Engineering;

    Sammanfattning : The aim of the present work was to get an overview of the steel cleanness in tool steel. Plant trial studies of three steel grades were done with different focuses.Firstly the change of the inclusion characteristics during the vacuum degassing in the ladle was looked upon. LÄS MER