Sökning: "Muliple sclerosis"

Hittade 2 avhandlingar innehållade orden Muliple sclerosis.

  1. 1. Epidemiological and genetic studies of muliple sclerosis with focus on the Swedish county of Värmland

    Författare :Margarita Callander; Anders Svenningsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inborn genetic diseases; Genetic predisposition to disease; Genetic predisposition to disease; Cluster analysis; Muliple sclerosis; Pedigree; Medical genetics; Medicinsk genetik;

    Sammanfattning : The aim of this study was to perform detailed investigations of a presumed high-risk area, namely the county of Värmland, to see if previous results from our group indicating a high frequency of multiple sclerosis (MS) could be confirmed. We soon identified an aggregation of MS cases in the parish of Lysvik located in the north of Värmland and initiated epidemiological and genetical analyses of the population. LÄS MER

  3. 2. Markers of inflammation and neurodegeneration in muliple sclerosis

    Författare :Virginija Danylaitė Karrenbauer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main line of my thesis projects is searching for biomarkers and evidence of optimal correlation with clinical and para-clinical outcome measurements in multiple sclerosis (MS): investigating the biochemical biomarker in blood/plasma (cerebrosterol) and in cerebrospinal fluid (CSF) (oligoclonal bands (OCB)) and the correlation with MRI lesion load (paper 1 and paper IV); investigating the genetic biomarker (CYP46A1) for susceptibility and disability progression in MS (Paper III); comparison of the well-known positron emission tomography (PET) ligand and peripheral benzodiazepine receptor (PBR) antagonist, [11C]PK11195, and a new PET ligand [11C]vinpocetine (tissue receptor biomarker). Both ligands denote areas of active ongoing inflammation in MS (paper II). LÄS MER