Sökning: "Molecular docking"
Visar resultat 16 - 20 av 98 avhandlingar innehållade orden Molecular docking.
16. Specific signaling through heteromeric PDGF receptor complexes
Sammanfattning : Platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal cells and exert its effect by binding to two structurally related receptor tyrosine kinases, denoted α- and β-receptors. PDGF binding induces dimerization of its receptors, both homo-and heterodimerization, leading to their autophosphorylation on tyrosine residues and binding of downstream signaling molecules. LÄS MER
17. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors
Sammanfattning : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. LÄS MER
18. In silico Identification of Thyroid Disrupting Chemicals : among industrial chemicals and household dust contaminants
Sammanfattning : Thyroid disruptions by xenobiotics have been associated with a broad spectrum of severe adverse human health effects, such as impaired brain development and metabolic syndrome. Ingestion of indoor dust and contact with industrial chemicals are two significant human exposure routes of thyroid hormone disrupting chemicals (THDCs), raising serious concerns for human health. LÄS MER
19. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties
Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER
20. Molecular Probing of Local Protein-Protein Interactions : Studies of the tissue factor, factor VIIa complex formation
Sammanfattning : Protein-protein interactions are intrinsic to virtually all cellular processes. However, very little is known about the dynamics of the formation of protein complexes or the order of events that direct the association between two protein molecules (the association pathway), especially when different interacting surfaces are involved. LÄS MER
