Sökning: "Minor groove binder"

Hittade 2 avhandlingar innehållade orden Minor groove binder.

1. 1. DNA-Complexes with Drugs and Proteins

   Författare :Louise Fornander; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Circular Dichroism; Linear Dichroism; Minor groove binder; DNA strand exchange; HsRad51; Isothermal Titration Calorimetry; Hoechst 33258;

   Sammanfattning : DNA is fundamental for all living cells; the DNA holds the genetic code, which is more or less the instruction book for how all cells are built and function. Several diseases are also linked to DNA, emerging either from a mutation in our genome, which could result in a malfunctioning protein, or that the transcription of genes is somehow affected by structural changes in the DNA, induced by mutations or DNA binding molecules. LÄS MER

3. 2. Biophysical studies of DNA binding – by the large filament-forming protein Rad51 and the small minor-groove binder Hoechst 33258

   Författare :Louise Fornander; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Rad51; Linear Dichroism; DNA; Isothermal Titration Calorimetry.; Spectroscopy; Nanofluidics; Hoechst 33258; DNA-binding ligands;

   Sammanfattning : Mechanistic insight into the nature of DNA-binding ligands is crucial for both drug development as well as understanding more complex biological reactions that take place in the cell. In this Thesis, two rather different DNA-binding molecules are considered: 1. LÄS MER