Sökning: "Michael Smith"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Michael Smith.

1. 1. The impact of railway vibration and noise on sleep

   Författare :Michael Smith; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; railway vibration; noise; sleep disturbance; polysomnography; cardiovascular disease;

   Sammanfattning : Sleep is a vital component of good health, and sleep loss is associated with impaired cognition, decreased psychomotor performance, cardiovascular disease, adverse effects on endocrine and metabolic function, negative mood, impaired memory, and more. A growing burden of freight transportation on global railway networks will likely lead to an increase in nocturnal vibration and noise at nearby dwellings. LÄS MER

3. 2. The SHB adaptor protein in human and murine leukemia

   Författare :Maria Jamalpour; Michael Welsh; Edvard Smith; Uppsala universitet; []
   Nyckelord :;

   Sammanfattning : The SHB adaptor protein operates downstream of tyrosine kinase receptors. It has been found previously that Shb deficiency in hematopoietic stem cells (HSCs) results in less proliferation and failure to maintain the myeloid compartment over time. LÄS MER

4. 3. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

   Författare :Kristin E Karlsson; E Niclas Jonsson; Mats O Karlsson; Anders Grahnén; Michael K Smith; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Sammanfattning : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. LÄS MER

5. 4. Förstaspråksattrition hos vuxna : Exemplet polsktalande i Sverige

   Författare :Dorota Lubińska; Kenneth Hyltenstam; Michael Sharwood Smith; Stockholms universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; first language attrition; Polish language; Polish immigrants; verbal government; hesitation phenomena; pro-drop parameter; genitive; genitive of negation; reflexive verbs; masculine declension; language attitudes; language use; jezyk polski w Szwecji; atrycja; dwujezycznosc; gramatyka polska; emigracja polska w Szwecji; Bilingualism; Tvåspråkighet; tvåspråkighetsforskning; Bilingualism;

   Sammanfattning : This thesis is concerned with adult L1 attrition in the case of highly-educated long-term Polish immigrants in Sweden. The study sheds light on two classical issues pertaining to L1 attrition, namely what happens to a fully developed mature language system in an immigrant context, and why it happens. LÄS MER

7. 5. Submicrometre aerosol emissions from sea spray and road traffic

   Författare :Monica Mårtensson; Douglas Nilsson; Christer Johansson; Michael Smith; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Eddy covariance method; aerosol emissions; submicrometre sea salt parameterisation; primary marine organic aerosols; sea spray; road traffic emission factors; air-sea exchange; aerosol dynamics model; internal aerosol mixing; combustion aerosols; Atmosphere and hydrosphere sciences; Atmosfärs- och hydrosfärsvetenskap; atmosfärvetenskap; Atmospheric Sciences;

   Sammanfattning : The uncertainty of the climate and health effects of aerosols is still large, one important reason being lack of knowledge of the primary emissions. This thesis combines laboratory and field experiments, and process modelling in an effort to better quantify the submicrometre aerosol emissions and to understand some of the processes in the atmosphere. LÄS MER