Sökning: "Mendelian randomization"
Visar resultat 1 - 5 av 33 avhandlingar innehållade orden Mendelian randomization.
1. Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization
Sammanfattning : Type 2 diabetes (T2D) and cardiovascular disease (CVD) are highly prevalent complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. LÄS MER
2. Genetic factors affecting pregnancy duration in humans
Sammanfattning : This thesis investigates the mechanisms behind human pregnancy duration. Too short gestation is a direct cause of perinatal, neonatal, and infant mortality. Deviation from normal pregnancy length is also associated with a child's morbidity, even in the adulthood. LÄS MER
3. Optimizing Exposome-wide Assessments in Cardiometabolic Risk
Sammanfattning : This thesis is focused on cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D), two concomitant conditions that appear with growing concern. In our work, we aim to improve the identification of individuals at-risk of cardiometabolic disease through the characterization of complex environmental exposures (i.e. LÄS MER
4. Understanding the genetic architecture of fatty liver disease
Sammanfattning : Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, ranging from simple steatosis to more severe conditions, namely non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). NAFLD has a strong genetic component, and its heritability depends on environmental factors and ethnicity. LÄS MER
5. Interplay between genetics and environment in obesity
Sammanfattning : Background. Being one of the largest current global health problems, obesity is a result of interplay between genetic and environmental factors. LÄS MER