Sökning: "Membrane organization"

Visar resultat 1 - 5 av 95 avhandlingar innehållade orden Membrane organization.

  1. 1. Cholesterol in T cells : homeostasis, plasma membrane organization and signaling

    Författare :Saleemulla Mahammad; Ingela Parmryd; Thomas Harder; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plasma membrane; T cells; Cholesterol; Lipid rafts; Membrane organization; Cholesterol homeostasis; cholesteryl esters; Cell biology; Cellbiologi; Cell Biology; cellbiologi;

    Sammanfattning : The plasma membrane of eukaryotic cells contains cholesterol and glycosphingolipids enriched nanodomains known as lipid rafts; which are believed to exist in a liquid ordered (lo) state. Methyl-beta-cyclodextrin (MBCD) is used to deplete cellular cholesterol and a widespread assumption is that MBCD preferentially targets cholesterol in lipid rafts. LÄS MER

  3. 2. The role of nuclear membrane proteins in differentiation and chromatin organization

    Författare :Cecilia Bergqvist; Einar Hallberg; Neus Visa; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nuclear membrane proteins; chromatin organization; epigenetics; differentiation; stem cells; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The nuclear envelope, consisting of an outer and an inner nuclear membrane, surrounds the genomic material. The genomic material (chromatin) is highly structured with (transcriptionally inactive) heterochromatin mostly found in the nuclear periphery and (transcriptionally active) euchromatin mostly found in the nuclear interior. LÄS MER

  4. 3. Apoptosis Regulation via the Mitochondrial Pathway : Membrane Response upon Apoptotic Stimuli

    Författare :Marc-Antoine Sani; Gerhard Grobner; Antoinette Killian; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Apoptosis; BH4 peptide; Bax-α1 peptide; model membrane; cardiolipin; solid phase peptide synthesis; circular dichroism; solid-state nuclear magnetic resonance spectroscopy.; Biophysics; Biofysik;

    Sammanfattning : The aim of this thesis was the investigation of the mitochondrial response mechanisms upon apoptotic stimuli. The specific objectives were the biophysical characterization of membrane dynamics and the specific roles of lipids in the context of apoptotic regulation occurring at the mitochondrion and its complex membrane systems. LÄS MER

  5. 4. Plasma membrane order; the role of cholesterol and links to actin filaments

    Författare :Jelena Dinic; Ingela Parmryd; Gerrit van Meer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Membrane Organization; Lipid rafts; Actin; Laurdan; di-4-ANEPPDHQ; Cholesterol; T cell signaling; Colocalization; Generalized Polarization; Cell Biology; cellbiologi;

    Sammanfattning : The connection between T cell activation, plasma membrane order and actin filament dynamics was the main focus of this study. Laurdan and di-4-ANEPPDHQ, membrane order sensing probes, were shown to report only on lipid packing rather than being influenced by the presence of membrane-inserted peptides justifying their use in membrane order studies. LÄS MER

  7. 5. Photosystem II : organization, function and regulation

    Författare :Said Eshaghi; Matthias Rögner; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biogeochemistry; biogeokemi;

    Sammanfattning : What makes plants, green algae and cyanobacteria so remarkable is their ability to convert light energy to chemical energy and at the same time evolve oxygen. In order to do so, they have developed a complex molecular machinery involving pigment and co-factor binding multi-protein complexes. LÄS MER