Sökning: "Medicine human and vertebrates"

Visar resultat 11 - 15 av 198 avhandlingar innehållade orden Medicine human and vertebrates.

  1. 11. Studies on intrinsic and extrinsic sources of variability in pharmacokinetics and pharmacodynamics

    Författare :Johanna Mercke Odeberg; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxikologi; pharmacy; pharmacognosy; Pharmacological sciences; Medicin människa och djur ; Medicine human and vertebrates ; genetic polymorphisms UGT1A-and MDR1 gene ; indirect response model; desmopressin; oral lipid based formulations; farmaci; Farmakologi; toxicology; farmakognosi;

    Sammanfattning : Variability in pharmacokinetic and pharmacodynamic parameters between individuals can be due to intrinsic and extrinsic factors. In this thesis three different areas regarding sources of variability have been investigated. 1. Formulation properties as an extrinsic source of variability. LÄS MER

  3. 12. Membrane traffic in neutrophils and neutrophil-like cells

    Författare :Susanne Bauer; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infections; membrane traffic; Hematologi; extracellular fluids; Haematology; Medicin människa och djur ; Medicine human and vertebrates ; CD177; extracellulära vätskor; PR3; phagocytosis; Streptococcus pyogenes; Infektioner; neutrophils;

    Sammanfattning : The neutrophil constitutes the first line of defence against invading organisms and its primary function is to recognize, phagocytose and kill intruding microorganisms. In this thesis, the membrane traffic in neutrophils and neutrophil-like cells was studied. Non-opsonised S. LÄS MER

  4. 13. Genetic and genomic analysis of arthritis regulating regions in human and mouse

    Författare :Lina Olsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Immunologi; serologi; transplantation; Skeleton; muscle system; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; QTL; NADPH oxidase complex; Rheumatoid Arthritis; Genetic Analysis;

    Sammanfattning : Identifying genes involved in the disease pathways of complex diseases such as Rheumatoid arthritis (RA) has been shown to be very difficult. Despite decades of research still only a handful of genes have been convincingly identified as risk genes. LÄS MER

  5. 14. Alpha-1-microglobulin, heme-binding protein, reductase and antioxidant

    Författare :Maria Allhorn; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reduction; inflammation; chronic ulcers; collagen; low density lipoproteins; Medicin människa och djur ; Medicine human and vertebrates ; antioxidation; heme; hemoglobin; alpha-1-microglobulin; lipocalin;

    Sammanfattning : This thesis describes structural and functional studies of alpha-1-microglobulin (a1m), a 26 kDa plasma and tissue protein that is evolutionarily well-conserved and belongs to the lipocalin superfamily. The lipocalins are polypeptides of 160-190-amino acids that are folded into an 8-stranded beta-barrel forming a pocket with a hydrophobic interior. LÄS MER

  7. 15. Smoking and airway disorders in an urban population -special references to gender and socioeconomic status

    Författare :Marie Ekberg; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Folkhälsa; epidemiology; Public health; Andningsorganen; Respiratory system; gender; COPD; hospital admissions; lung cancer; Medicine human and vertebrates ; tobacco; socio-economic status; smoking; population-based; morbidity; mortality; epidemiologi; lung function; Medicin människa och djur ; women;

    Sammanfattning : The Malmö Preventive Project, a preventive, case-finding programme for cardiovascular risk factors and alcohol abuse was created in 1974 at the Department of Preventive Medicine of Malmö University Hospital. Between 1974-1992, a total of 22 444 men (mean age 44 years range 27 - 61) and 10 902 women (mean age 50 years, range 28 - 58) attended the programme, with an overall attendance rate of 70% (range 64-78). LÄS MER