Sökning: "Markus Johnsson"

Hittade 2 avhandlingar innehållade orden Markus Johnsson.

  1. 1. Sterically stabilised liposomes and related lipid aggregates Fundamental studies on aggragate structure and stability

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Markus Johnsson; Uppsala universitet.; [2001]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physics; liposome; steric stabilisation; colloidal stability; cryo-TEM; drug delivery; Fysik; NATURAL SCIENCES Physics; NATURVETENSKAP Fysik; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : Various aspects of and approaches towards the steric stabilisation of liposomes have been investigated, mainly by use of fluorescence techniques and cryo-transmission electron microscopy (cryo-TEM). It is shown that PEG(2000)-lipids can be incorporated in the liposome membrane up to a critical concentration of 8-10 mol% without any observable structural perturbations. LÄS MER

  2. 2. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion

    Detta är en avhandling från Divison of Hematology and Transfusion Medicine, Lund University

    Författare :Ying Gao; Lunds universitet.; Lund University.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; extracellulära vätskor; Hematologi; Medicin människa och djur ; Haematology; Medicine human and vertebrates ; neutrophil; granule; secretory lysosome; sorting; phagocytosis; degranulation.; mast cell; hematopoietic cell; inflammation; soluble TNF receptor;

    Sammanfattning : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. LÄS MER