Sökning: "MSH"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet MSH.

  1. 1. Mutational analysis of melanocortin receptors 1 and 5

    Författare :Per-Anders Frändberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Melanocortin receptor; melanocortin peptide; MSH; NDP-MSH; mutagenesis human phenotype; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : The melanocortin receptor family includes five subtypes, named MC1R to MC5R. Melanocortin receptors are predominantly coupled to second messenger pathway of cyclic AMP through coupling to G-protein. This study is focused on structure-function relationship of MC1R and MC5R. LÄS MER

  3. 2. Cloning, Expression, Pharmacological Characterization and Anatomical Distribution of Melanocortin Receptors in an Evolutionary Perspective

    Författare :Aneta I. Ringholm; Helgi B. Schiöth; Dan Larhammar; Björn Olde; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; evolution; melanocortin; MSH; pharmacology; genome duplication; tetraploidization; zebrafish; spiny dogfish; chicken; GPCR; polymorphism; pigmentation; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Sammanfattning : The melanocortin (MC) receptors are G-protein coupled receptors thatparticipate in several important physiological functions such as the regulation of the energy balance. This thesis focuses on the evolutionary aspect of the MC receptors and their pharmacology.One MC4 receptor and two MC5 receptor subtypes were found in a teleost fish, zebrafish. LÄS MER

  4. 3. alpha-Melanocyte-stimulating hormone in neurodegenerative processes

    Författare :Åsa Forslin Aronsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :alpha-MSH; excitotoxicity; gliosis; ischemia; memory; stereology;

    Sammanfattning : The fact that inflammatory processes accompany the neuronal cell death in most neurodegenerative disorders, has in recent years inspired to studies on the role of inflammation in the brain and the possibility to prevent or stop the degenerative processes by treatment with anti-inflammatory drugs. Neurodegenerative disorders are often accompanied by a progressive loss of memory, and substances that can improve memory functions are of great interest. LÄS MER

  5. 4. Maximal step-up height as a novel assessment of leg muscle strength and function : methodological and clinical studies

    Författare :Lillemor Amanda Nyberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Physical performance is a strong predictor for morbidity and premature death and there is an increasing interest in the role of sarcopenia in many chronic diseases. There is a need for simple, robust and valid tests for assessing muscle strength and function in clinical practice. LÄS MER

  7. 5. Hormonal Regulation of Neural Stem Cell Proliferation and Fate Determination

    Författare :Karin Brännvall; Dan Lindholm; Sandra Ceccatelli; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neural stem cell; Proliferation; Fate determination; Hormones; Anabolic androgenic steroids; Neurovetenskap; Neurology; Neurologi;

    Sammanfattning : Stem cells have the capacity for both self renewal, and to form all cell types in the body. Interestingly, so called neural stem cells (NSCs) are found in the adult human brain, which is of significance both out of a developmental perspective and from a clinical point of view. LÄS MER