Sökning: "MI"

Visar resultat 1 - 5 av 318 avhandlingar innehållade ordet MI.

  1. 1. Functional genomics approaches to dissect causal DNA variations in obesity and type 2 diabetes

    Författare :Mi Huang; Genetisk och molekylär epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; Obesity; Type 2 diabetes; CRISPR Cas9; precision medicine; adipocytes; functional genomics;

    Sammanfattning : GWAS studies have identified hundreds of loci that associate with obesity and type 2 diabetes. However, the functional relevance of the genetic variants, and their impact on disease or traits, is largely unknown. LÄS MER

  3. 2. Preservation of male fertility in childhood acute leukemia : an experimental study addressing novel strategies and putative risks

    Författare :Mi Hou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Although treatment of cancer in young boys with cytotoxic agents has long been known to cause infertility in the survivors, the mechanisms underlying drug-induced damage to the immature testis remain unclear. A number of clinical issues associated with transplantation of testicular germ cells or tissues also require clarification. LÄS MER

  4. 3. The trident of the pancreatic duct : stemness, morphogenesis and endocrinogenesis

    Författare :Jiarui Mi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Different subtypes of diabetes are all featured by the deterioration and loss of functional β-cell. Currently, there is still lack of therapeutic strategies to cure diabetes. However, harnessing the innate stem cell population to become functional β-cell could be a potential way for future treatment. LÄS MER

  5. 4. Dopamine receptors in the rat brain

    Författare :Mi Hillefors-Berglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine D2 receptors; Dopamine D3 receptors; Rat; Autoradiography; [3H]7-OH-DPAT; [3H]PD 128907; Caudate-putamen; Subcortical limbic area; Islands of Calleja; CGS 21680; Toluene; Neurotensin; Asphyxia; Aging; Magnesium; GTP;

    Sammanfattning : Dopamine receptors belong to a large superfamily of G protein-coupled receptors and consist of the D1, D2, D3, D4, and D5 receptors. The D2, D3, and D4 receptors belong to the D2 receptor family which is characterized by having a large third cytoplasmic loop and a short C-terminus projecting into the cytosol, and by inhibiting the enzyme adenylyl cyclase. LÄS MER

  7. 5. Cytochrome P450 pharmacogenetics : implications for anticancer and warfarin therapy

    Författare :Mi-Young Lee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : There is a pronounced interindividual variability in the drug disposition, response and toxicity. Pharmacogenetics aims at identifying genetic biomarkers that could help to increase the drug efficacy, reduce adverse drug reactions and contribute to the development of personalized medicine. LÄS MER