Sökning: "MGST1"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet MGST1.

  1. 1. The kinetic mechanism of microsomal glutathione transferase 1 (MGST1)

    Författare :Richard Svensson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glutathione; glutathione transferase; enzyme mechanism; pre-steady state kinetics; steady state kinetics; membrane protein; xenobiotic metabolism.;

    Sammanfattning : Microsomal glutathione transferase I (MGST1) is a homotrimeric membrane-bound enzyme involved in detoxication of numerous toxic electrophilic compounds, e.g. halogenated alkenes and arenes, alpha, beta-unsaturated hydrocarbons and peroxides. MGST1 is expressed in large amounts in most organs, which speaks for an important role for this enzyme. LÄS MER

  3. 2. Molecular genetic studies of oxidative stress related genes

    Författare :Louise Lyrenäs; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gene regulation; oxidative stress; genetic variation; catalase; MGST1; PGES;

    Sammanfattning : This work has focused on the basal characterisation of transcriptional regulation, including genetic variants, in oxidative stress related genes and the possible impact of such variation in cardiovascular disease. The genes under study were catalase and MGST1/PGES where the two former protect from hydrogen peroxide and lipid hydroperoxides respectively and the latter is important in e. LÄS MER

  4. 3. Microsomal glutathione transferase 1 in anti-cancer drug resistance and protection against oxidative stress

    Författare :Katarina Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is the second leading cause of death in privileged countries. Tremendous efforts have been done to improve the efficiency of cancer treatment. Anti-cancer drug resistance is still a major problem in failure of cancer therapy. LÄS MER

  5. 4. Structural and functional studies of microsomal glutathione transferase 1

    Författare :Peter J Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glutathione transferase; membrane protein; three-dimensional structure; elecron crystallography; hydrophobic binding stoichiometry; H D exchange mass spectrometry;

    Sammanfattning : The microsomal glutathione transferase 1 (MGST1) is present in high amounts in the endoplasmic reticulum (ER) as an integral homo-trimeric membrane protein with a molecular weight of 51.9 kDa. LÄS MER

  7. 5. Ligand binding and mechanism of microsomal glutathione transferase 1

    Författare :Johan Ålander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The homo-trimeric, membrane bound Microsomal Glutathione Transferase 1 (MGST1, EC. 2.5.1. LÄS MER