Sökning: "Leonard Girnita"

Hittade 1 avhandling innehållade orden Leonard Girnita.

1. 1. Growth factor pathways in human cancer : functional and therapeutic implications

   Författare :Leonard Girnita; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF-1R; growth factors; p53; fusion protein; tyrosine kinase inhibitors; ubiquitin;

   Sammanfattning : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. LÄS MER