Sökning: "Lars Ekholm"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Lars Ekholm.
1. Soluble amyloid-β aggregates in Alzheimer’s disease
Sammanfattning : Soluble oligomeric aggregates of the amyloid-β (Aβ) peptide are suggested to initiate Alzheimer's disease (AD), leading to impaired synapse signalling, widespread neuronal death and loss of cognitive functions. These aggregates seem tightly linked to disease progression, and have therefore gained much attention as potential novel disease markers. LÄS MER
2. Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model
Sammanfattning : The Arctic mutation causes early-onset Alzheimer’s disease (AD), and makes amyloid-β (Aβ) peptides more prone to form Aβ protofibrils. The aims of this thesis were to investigate the mechanisms of the Arctic mutation in vivo, and to use transgenic models to determine the role of early intermediates of Aβ aggregation, like protofibrils, in the pathogenesis. LÄS MER
3. Svensk krigsfinansiering 1630-1631
Sammanfattning : .... LÄS MER
4. Identical, But Still Different : On Artistic Appropriation in Visual Art
Sammanfattning : In this dissertation about artistic appropriation I acknowledge that something indeed has happened in art. Visual art does not have to look in any special way anymore, or have historically validated content that can be visually grasped. Within this precondition artistic appropriation is situated. LÄS MER
5. Amyloid-β Protofibril Formation and Neurotoxicity : Implications for Alzheimer’s Disease
Sammanfattning : Alzheimer’s disease (AD) is the most common cause of dementia. A characteristic feature of AD is the presence of amyloid plaques in the cortex and hippocampus of the brain. The principal component of these plaques is the amyloid-β (Aβ) peptide, a cleavage product from proteolytic processing of amyloid precursor protein (APP). LÄS MER
