Sökning: "LNCaP"

Visar resultat 6 - 10 av 21 avhandlingar innehållade ordet LNCaP.

  1. 6. The role of androgen in prostate cancer cell invasion

    Författare :Yin-Choy Chuan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostate cancer (PCa) is the most commonly diagnosed cancer in men in developed countries. Androgen deprivation therapy (ADT) is the mainstay treatment for patient diagnosed with PCa. However, the cancer will eventually relapse with metastatic cancer and become resistant to the treatment. LÄS MER

  3. 7. Radioimmunoimaging and Radioimmunotherapy of Prostate Cancer Preclinical evaluation of kallikrein related peptidase 2 targeting

    Författare :Oskar Vilhelmsson Timmermand; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radioimmunoimaging; radioimmunotherapy; antibody; 11B6; indium-111; lutetium-177; kallikrein related peptidase 2; hK2; PSA; prostate cancer; SPECT; KLK2; cherenkov luminescence imaging; CLI;

    Sammanfattning : Prostate cancer is one of the major causes of cancer related deaths in men in Europe and the United States. In this doctoral thesis, radioimmunoimaging and -therapy of prostate cancer was investigated pre-clinically by targeting the human kallikrein-related peptidase 2 (hK2) with radiolabelled monoclonal antibodies. LÄS MER

  4. 8. Adenovirus-mediated Gene Therapy of Prostate Cancer

    Författare :Angelika Danielsson; Mangus Essand; Thomas H. Tötterman; Gunnel Hallden; Uppsala universitet; []
    Nyckelord :adenovirus; adenoviral vector; oncolytic virus; gene therapy; prostate cancer; PEGylation; HDAC inhibitor; whole blood model; whole blood neutralization assay; MEDICINE; MEDICIN; Klinisk immunologi; Clinical Immunology; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Adenovirus-mediated gene therapy is a potential complement to standard cancer treatments. Advantages are that vectors can be used to target tumors and that replicating viruses lead to increased therapeutic dosage. LÄS MER

  5. 9. Somatostatin effects on the proteome of human prostate cancer cells

    Författare :Zhaoxu Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The transition of prostate cancer from androgen dependent to the therapy resistant androgen independent state, is a large and persistent problem in the clinical management of prostate cancer. The aim of this thesis was to study somatostatin effects on the proteome of prostate cancer cells, to identify differences in protein expression in androgen dependent and androgen independent prostate cancer cells, and to explore possibilities to enhance the somatostatin receptor expression through pre-treatment with sms, 5-aza and TSA (DNA methylation/HDAC inhibitors). LÄS MER

  7. 10. Tools for the Advancement of Radiopharmaceutical Therapy

    Författare :Emma Mellhammar; Forskningsgruppen för Systemisk strålterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiopharmaceutical therapy; Nuclear medicine; Monte Carlo simulation; Intratherapeutic preclinical PET; Alpha particles; Beta Particles; radionuclides; Radiobiology; γ-H2AX; Dosimetry;

    Sammanfattning : Radiopharmaceutical therapy is used to treat cancers and other diseases with radiolabeled pharmaceuticals. The treatment targets specific cells, and the emitted ionizing radiation cause cytotoxic damage. Dosimetry is performed to estimate the absorbed dose from the energy deposited in the body. LÄS MER