Sökning: "LIMD1 LIM-domain containing gene 1"

Hittade 2 avhandlingar innehållade orden LIMD1 LIM-domain containing gene 1.

  1. 1. Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3

    Författare :Hajnalka Kiss; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Elimination test; common eliminated region 1 CER1 ; 3p21.3; tumor suppressor gene; large scale sequencing; LIMD1; LZTFL1; FYC01; TMEM7; LRRC2; LUZP3.;

    Sammanfattning : An experimental system, called the elimination test (Et), was developed to identify tumor growth antagonizing genes. Chromosome 3 containing microcell hybrids (MCHs) were passaged through SCID mice and regular deletion of the short arm of chromosome 3 (3p) were found by cytogenetic and molecular methods. LÄS MER

  3. 2. Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'

    Författare :Ying Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Elimination test; common eliminated region 1 CER1 ; 3p21.3; microcell hybrids; tumor suppressor gene; LF lactoferrin ; LIMD1 LIM-domain containing gene 1 ; sequencing; MMCT microcell mediated chromosome transfer ; real time PM methylation;

    Sammanfattning : The aim of elimination test (Et) is to identify tumor antagonizing genes from chromosome regions that are regularly deleted in microcell hybrid (MCH) derived tumors through serial SCID mice passages. Et so far was focused on the short arm of human chromosome 3 (chr 3) due to its frequent deletions in 21 tumor types including renal cell carcinoma (RCC), small cell lung carcinoma (SCLC) and breast cancer (BRC). LÄS MER