Sökning: "Klas Wiman"

Hittade 5 avhandlingar innehållade orden Klas Wiman.

  1. 1. HLA-DR transplantation antigens : tissue distribution and structure

    Författare :Klas Wiman; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Astrocyte elevated gene-1 in relation to colorectal cancer development and radiotherapy response

    Författare :Sebastian Gnosa; Xiao-Feng Sun; Hans Starkhammar; Hong Zhang; John Carstensen; Klas Wiman; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The incidence and death rate for colorectal cancer (CRC) decreased during the last decades as a result of improved diagnosis and treatment. However, CRC is still the third most common cancer in the world, and is responsible for about 700 000 deaths per year worldwide. LÄS MER

  4. 3. Cellular Pharmacology of the Novel Antitumoural Cyanoguanidine CHS 828

    Författare :Henrik Lövborg; Rolf Larsson; Peter Nygren; Klas Wiman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; CHS 828; Cyanoguanidines; Oncology; Pharmacology; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Sammanfattning : The antitumoural cyanoguanidine CHS 828 has shown promising activity in a number of preclinical and clinical studies. However, the mechanisms underlying the cell death induced by CHS 828 has not been clarified. This thesis describes in vitro studies of the cellular pharmacology of CHS 828. LÄS MER

  5. 4. The cell cycle regulators p18Ink4c and p19Ink4d : in vivo studies of their roles in tumorigenesis and development

    Författare :Lisa Nilsson; Olle Heby; Martine Roussel; Klas Wiman; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi;

    Sammanfattning : Progression through the G1, S, G2 and M phases of the cell cycle is controlled by cyclin-dependent kinases (Cdks) and cyclins. These proteins form active Cdk:cyclin complexes that phosphorylate specific substrates. LÄS MER

  7. 5. The Interaction of the Adenovirus E1B-55K Protein with a Histone Deacetylase Complex: Its Importance in Regulation of P53 Protein Functions

    Författare :Tanel Punga; Göran Akusjärvi; Klas G. Wiman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; adenovirus; E1B-55K; p53; histone acetylation; Sin3; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : The human tumour suppressor protein p53 is an effective inhibitor of cell growth, by inducing cell cycle arrest and apoptosis. However, p53-induced cell growth inhibition can be detrimental for virus multiplication. Therefore, viruses encode for proteins, which can interfere with the functions of the p53 protein. LÄS MER