Sökning: "Kemi med inriktning mot biofysik"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Kemi med inriktning mot biofysik.
1. Alexandria: A General Drude Polarizable Force Field with Spherical Charge Density
Sammanfattning : Molecular-mechanical (MM) force fields are mathematical functions that map the geometry of a molecule to its associated energy. MM force fields have been extensively used for an atomistic view into the dynamic and thermodynamics of large molecular systems in their condensed phase. LÄS MER
2. Structural Studies of Large dsDNA Viruses using Single Particle Methods
Sammanfattning : Structural studies of large biological assemblies pose a unique problem due to their size, complexity and heterogeneity. Conventional methods like x-ray crystallography, NMR, etc. are limited in their ability to address these issues. To overcome some of these limitations, single particle methods were used. LÄS MER
3. Imaging Living Cells with an X-ray Laser
Sammanfattning : Imaging living cells at a resolution higher than the resolution of optical microscopy is a significant challenge. Fluorescence microscopy can achieve a degree of super-resolution via labeling cellular components with a fluorescent dye. LÄS MER
4. The impact of GPCR structures on understanding receptor function and ligand binding
Sammanfattning : G protein-coupled receptors (GPCRs) form the largest superfamily of eukaryotic membrane proteins and are responsible for the action of nearly 30% of all marketed drugs. For a long period, efforts to study these receptors were limited by the paucity of atomic-resolution structural information. LÄS MER
5. Characterization and Engineering of Protein-Protein Interactions Involving PDZ Domains
Sammanfattning : The work presented in this thesis has contributed with knowledge to several aspects of protein-protein interaction involving PDZ domains. A substantial amount of our proteome contains regions that are intrinsically disordered but fold upon ligand interaction. LÄS MER
