Sökning: "Karin Anestål"

Hittade 1 avhandling innehållade orden Karin Anestål.

  1. 1. Mammalian thioredoxin reductase as a drug target in anticancer therapy through direct apoptosis induction by selenium compromised forms of the protein

    Författare :Karin Anestål; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thioredoxin reductase; TrxR1; SecTRAPs; selenoproteins; apoptosis; caspase-2; glutathione reductase; cisplatin;

    Sammanfattning : The mammalian thioredoxin system, consisting of thioredoxin(s), thioredoxin reductase(s) and NADPH, participates in the regulation of many important systems in a mammalian cell. The mammalian thioredoxin reductases (TrxR) are selenoproteins containing a selenocysteine (Sec) residue within a carboxyl terminal -Gly -Cys -Sec -Gly -COOH motif. LÄS MER