Sökning: "K-Cl cotransporter"

Hittade 5 avhandlingar innehållade orden K-Cl cotransporter.

  1. 1. Applying the Pump and Leak Hypothesis. An experimental and theoretical investigation of the principles of ion regulation and excitability in the crustacean stretch receptor neuron

    Författare :Sten Theander; Människan i rörelse: hälsa och rehabilitering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; lobster; stretch receptor neuron; leak current; Q-current; K-Cl cotransporter; A-current; mathematical model; excitability; GABA channel; neurophysiology; ion regulation; neuropsykologi; Neurologi; neurofysiologi;

    Sammanfattning : An invertebrate nerve cell preparation, the lobster stretch receptor neuron, was investigated with respect to maintenance of its resting voltage, intracellular ion concentrations and excitability using voltage clamp technique and ion-selective microelectrodes. It was found that the resting voltage (-65 mV) of microelectrode impaled cells is caused by (a) a homogenous population of K+ channels which we denoted as leak channels (b) an electrogenic and voltage-dependent Na-K pump current and (c) an inward microelectrode-induced "impalement" current carried mainly by Na+. LÄS MER

  3. 2. Chloride ion dynamics in neuronal homeostasis and plasticity: Measuring a zero current with a twitch of learning

    Författare :Christer Fåhraeus; Hjärnans sensorimotoriska funktioner; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; K-Cl cotransporter; Clˉ homeostasis; DIDS; SITS; bumetanide; mathematical modeling; intracellular glass microelectrode; electrodiffusion; electro-osmosis; tip potential; Hebb; learning;

    Sammanfattning : .... LÄS MER

  4. 3. Characterization of cochlear degeneration in the inner ear of the German waltzing guinea pig : a morphological, cellular, and molecular study

    Författare :Zhe Jin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cochlea; Deafness; Embryonic development; Inner ear; Melanocyte; Phenotype; Recessive genes; Recycling; Stria vascularis.;

    Sammanfattning : The German waltzing guinea pig is a new strain of animals with yet unknown gene mutation(s) displaying recessively inherited cochleovestibular impairment. The homozygous animals (gw/gw) are deaf already at birth and display Wpical waltzing behavior throughout life. LÄS MER

  5. 4. Cytoskeleton-interacting proteins in brainstem development : roles of KCC2 and Vangl2

    Författare :Zachi Horn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The brainstem is the most evolutionary conserved division of the brain. It develops from the hindbrain and midbrain regions of the neural tube and forms neural networks that regulate vital functions of the body. One of the most critical roles is to generate respiratory rhythm for the regulation of oxygen, carbon dioxide and pH levels. LÄS MER

  7. 5. Chloride Homeostasis in Central Neurons

    Författare :Tushar Yelhekar; Staffan Johansson; Michael Druzin; Merab Kokaia; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chloride concentration; current-voltage relation; interpolation; voltage ramp; reversal potential; [Cl–]i recovery; KCC2; extracellular matrix; GABAA receptor; chloride leak conductance; neurosteroid; fysiologi; Physiology;

    Sammanfattning : The overall aim of the present thesis is to clarify the control of intracellular chloride homeostasis in central neurons, because of the critical role of chloride ions (Cl–) for neuronal function. Normal function of the central nervous system (CNS) depends on a delicate balance between neuronal excitation and inhibition. LÄS MER