Sökning: "Janus kinase"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Janus kinase.

  1. 1. Receptors for growth hormone and prolactin. Regulation and activation

    Författare :Gunnel Hellgren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; GH receptor; Janus kinase; GH sensitivity; 5 -untranslated region; prolactin; prolactin receptor adipose tissue; liver; skeletal muscle; epidermal growth factor receptor; tyrosine kinase; kinase activity;

    Sammanfattning : Cytokine receptor activation is dependent on ligand-induced receptor dimerization or oligomerization and subsequent activation of several intracellular proteins. Activation of Janus kinases (Jaks) is probably the first intracellular event that occurs after receptor dimerization. LÄS MER

  3. 2. Molecular Mechanism of Growth Hormone - Involvement of Janus Kinase 2, Insulin Receptor Substrate-1 and -2 and Phosphatidylinositol 3-Kinase In the Acute Insulin-Like Effects of Growth Hormone In Primary Rat Adipocytes

    Författare :Martin Ridderstråle; Diabetes - klinisk obesitasforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin receptor substrate-1; insulin receptor substrate-2 phosphatidylinositol 3-kinase; signal transducer and activator of transcription 5; janus kinase 2; phosphotyrosine; receptor; phosphorylation; Growth hormone; Metabolism; Biochemistry; rat; adipocyte; lipolysis; lipogenesis; Biokemi; metabolism; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Originally studying the molecular mechanisms for the insulin-like effects of growth hormone (GH), lipogenesis and antilipolysis, in isolated rat adipocytes we found that the GH receptor (GHR) was tyrosine phosphorylated in response to GH in cells that were responsive to these effects. Then, as Janus kinase 2 (JAK2) was described as a GH-stimulated and GHR-associated tyrosine kinase, we found that JAK2 was tyrosine phosphorylated in response to GH in responsive cells. LÄS MER

  4. 3. Muscle Wasting in a Rat ICU Model : Underlying Mechanisms and Specific Intervention Strategies

    Författare :Heba Salah; Lars Larsson; Sven Tågerud; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BGP-15; critical illness myopathy; janus kinase; intensive care unit; mechanical loading; muscle wasting; signal Transducer and Activator of Transcription; ventilator-induced diaphragm dysfunction; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Clinical Neurophysiology; Klinisk neurofysiologi;

    Sammanfattning : Critical care has undergone several developments in the recent years leading to improved survival. However, acquired muscle weakness in the intensive care unit (ICU) is an important complication that affects severely ill patients and can prolong their ICU stay. LÄS MER

  5. 4. Regulation of STAT5 activity by growth hormone

    Författare :Tony J Pircher; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :growth hormone janus kinase; STAT5; MAP kinase; phosphatase;

    Sammanfattning : The growth hormone (GH) receptor is a member of the cytokine receptor superfamily. This receptor family has certain common characteristics, among them the absence of a canonical tyrosine kinase consensus sequence and the association with the Janus family of cytosolic tyrosine kinases (JAK). The predominant JAK utilized by the GH receptor is JAK2. LÄS MER

  7. 5. STAT5 expression and regulation in mammary epithelial cells

    Författare :Hanne Olsen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :STAT5; JAK2; PPAR-gamma; ER; MAPK; mammary epithelial cell differentiation;

    Sammanfattning : The mammary gland of an adult mammal undergoes cycles of proliferation and differentiation influenced by growth factors, peptide, and steroid hormones, e.g. epidermal growth factor (EGF), prolactin (PRL) and estrogen (E). LÄS MER