Sökning: "INS-1"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet INS-1.

  1. 1. Enterostatin - target proteins and intracellular mechanisms. Function in food intake and energy metabolism

    Författare :Karin Berger; Molekylär endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; energy metabolism; insulin; uncoupling protein; beta-casomorphin; opiate; SK-N-MC; INS-1; Medicin människa och djur ; Medicine human and vertebrates ; fat intake; F1F0-ATP synthase; appetite; enterostatin; satiety; obesity;

    Sammanfattning : Hunger and satiety are the results of complex neural events that involve several neurotransmitters and peptides. Enterostatin is an appetite-regulating peptide released in the intestine in response to fat ingestion. Enterostatin specifically decreases fat intake, but has also metabolic effects like inhibition of insulin secretion. LÄS MER

  3. 2. Intracellular signaling of phosphorylated insitol compounds : a study in pancreatic beta-cells and hippocampal neurons

    Författare :Jia Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :InsP6; L-type Ca 2 channel; hippocampal neuron; Ins 1; 4; 5 P3; Ca2 ; cyt-MIPP; pancreatic beta-cell; PtdIns 3; 4; 5 P3; Ptdlns 3; 5 P2.;

    Sammanfattning : The family of phosphorylated inositol compounds consists of soluble cytosolic inositol phosphates and insoluble inositol phospholipids, localized in cellular membranes and the nuclear matrix. Although inositol phospholipids only account for 5-10% of total plasma membrane lipids, these compounds and their inositol phosphate derivatives play an important role in a broad range of cellular processes including intracellular Ca 2+ signalling, ion channel regulation, vesicle trafficking, both exo- and endocytosis, cell growth and apoptosis. LÄS MER

  4. 3. Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP

    Författare :Ulrika Krus; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; Endocrinology; pyruvate dehydrogenase kinase; beta-cells; pyruvate carboxylase; diabetology; Endokrinologi; sekretion; diabetologi; diabetes;

    Sammanfattning : Type 2 diabetes is a disease that increases tremendously in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. LÄS MER

  5. 4. The impact of glucotoxicity on pancreatic β-cell function

    Författare :Sarheed Jabar Muhammed; Islet cell physiology; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP PKA system; iNOS; Type 2 diabetes; GSIS; PDE; GK rat; ZDF fa fa rat; GPR40; VDAC1; VDAC2; GSK-3β; ChREBP; TXNIP; resveratrol.;

    Sammanfattning : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. LÄS MER

  7. 5. Novel insights into the role of serotonin in control of β-cell fuction

    Författare :Hedvig Bennet; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. LÄS MER