Sökning: "IL-23"

Visar resultat 1 - 5 av 25 avhandlingar innehållade ordet IL-23.

1. 1. The IL-23 axis and innate immunity in the airways

   Författare :Marit Stockfelt; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-23; airways;

   Sammanfattning : The Interleukin-23 (IL-23) axis is a communication system that integrates innate and adaptive immunity. When triggered by microbial stimuli, antigen presenting cells can secrete the cytokine IL-23, leading to the production of IL-17 and IL-22. LÄS MER

3. 2. Modulatory role of IL-17 in airway inflammation

   Författare :Elin Silverpil; Göteborgs universitet; []
   Nyckelord :Respiratory medicine; Lung; IL-17; IL-23; Macrophages; Neutrophils; T cells; Apoptosis; Phagocytosis; Airways;

   Sammanfattning : IL-17 orchestrates the accumulation of neutrophils to sites of infection and the release of microbicidal substances, and therefore plays a critical role in the innate immune response to infection. IL-17 is also involved in certain chronic inflammatory diseases in which dysfunctional control of neutrophil accumulation and turnover constitutes an important pathogenic factor. LÄS MER

4. 3. Interleukin 15 and 17 in Staphylococcus aureus arthritis

   Författare :Louise Henningsson; Göteborgs universitet; []
   Nyckelord :Staphylococcus aureus; Interleukin-17A; Interleukin-15; arthritis; osteoclasts; IL-23;

   Sammanfattning : Staphylococcus aureus–induced arthritis leads to severe joint destruction and high mortality despite antibiotic treatment. Thus, there is a need to identify new treatment targets in addition to antibiotic therapy. Interleukin (IL)-15 has been implicated both in osteoclastogenesis and in bacterial clearance – two important issues in S. LÄS MER

5. 4. Macrophages : as central inflammatory mediators and as targets for therapeutic interventions

   Författare :Åsa Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Macrophages; HMGB1; IL-23; MS; EAE; autoimmunity.;

   Sammanfattning : Macrophages (Mphis) are important cellular players in autoimmune pathogenesis, being the most numerous cells infiltrating sites of inflammation and causing much of the associated tissue damage. Apart from these proinflammatory actions, Mphis also have distinct roles in disease resolution, and effective therapeutic targeting of Mphi-expressed molecules requires understanding of the interplay between different Mphi activators and the kinetics of the induced responses. LÄS MER

7. 5. Interleukin-17 in models of neutrophilic lung disease

   Författare :Stefan Ivanov; Göteborgs universitet; []
   Nyckelord :Interleukin-17; Interleukin-23; Matrix metalloproteinase-9; neutrophils; macrophages; CD4 cells; innate response; lungs;

   Sammanfattning : Several acute or chronic lung disorders like adult respiratory distress syndrome, acute severe asthma, chronic obstructive pulmonary disease, chronic lung allograft rejection and cystic fibrosis, are associated with signs of an excess innate response in the bronchoalveolar space. Neutrophils may play a pathogenic role in these lung diseases by contributing to non-specific bronchial hyperresponsiveness and bronchial hypersecretion, as well as to epithelial damage and tissue remodelling. LÄS MER