Sökning: "IBMIR"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet IBMIR.

  1. 1. Mechanisms and Therapeutic Interventions of Instant Blood-Mediated Inflammatory Reaction (IBMIR)

    Författare :Helena Johansson; Bo Nilsson; Olle Korsgren; Kristina Nilsson-Ekdahl; Tomas Lindahl; Uppsala universitet; []
    Nyckelord :Immunology; Diabetes; Islet transplantation; Islets of Langerhans; Coagulation activation; Complement activation; IBMIR; Tissue factor; Low molecular weight dextran sulfate; Immunologi;

    Sammanfattning : Intraportal transplantation of isolated islets of Langerhans is a procedure approaching clinical acceptance as a treatment for patients with type I diabetes mellitus. One major problem with this treatment is that large amounts of cells are lost at the time of infusion into the portal vein, resulting in a low level of engraftment of the islets. LÄS MER

  3. 2. The Role of Innate Immunity in Islet Transplantation : Clinical and Experimental Studies

    Författare :Lisa Moberg; Bo Nilsson; Olle Korsgren; Kristina Nilsson Ekdahl; Rolf Larsson; David Harlan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; diabetes; islet transplantation; islet of Langerhans; coagulation activation; IBMIR; tissue factor; thrombin; inactivated FVIIa; melagatran; neutrophilic granulocyte; Immunologi; Immunology; Immunologi;

    Sammanfattning : Clinical islet transplantation is an emerging procedure to cure type 1 diabetes. The graft is implanted by infusion into the liver through the portal vein. A major obstacle that still needs to be overcome is the requirement for islets from multiple donors to achieve insulin independence. LÄS MER

  4. 3. Pancreatic Islet Transplantation : Modifications of Islet Properties to Improve Graft Survival

    Författare :Sanja Cabric; Olle Korsgren; Bo Nilsson; Peetra Magnusson; Michael Breimer; Uppsala universitet; []
    Nyckelord :Medicine; Diabetes; islet transplantation; islets of Langerhans; coagulation activation; IBMIR; hirudin; heparin; growth factor; angiogenesis; Medicin;

    Sammanfattning : During the past decade clinical islet transplantation has become a viable strategy for curing type 1 diabetes. The limited supply of organs, together with the requirement for islets from multiple donors to achieve insulin independence, has greatly limited the application of this approach. LÄS MER

  5. 4. Studies of Innate and Adaptive Immunity in Islet Transplantation

    Författare :Maria Hårdstedt; Olle Korsgren; Bo Nilsson; Thierry Berney; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; islet transplantation; islets of Langerhans; xenotransplantation; nonhuman primate; blood; whole blood model; innate immunity; adaptive immunity; IBMIR; chemokines;

    Sammanfattning : Clinical islet transplantation is today an established alternative treatment for a selected group of type 1 diabetes patients. The predominant technique for transplantation is infusion of islets in the liver via the portal vein. LÄS MER

  7. 5. Imaging Islets of Langerhans by Positron Emission Tomography : Quantification of Beta-Cell Mass in the Native Pancreas and the Islet Graft

    Författare :Olof Eriksson; Anders Sundin; Olle Korsgren; Bengt Långström; Bo Nilsson; Håkan Ahlström; Habib Zaidi; Uppsala universitet; []
    Nyckelord :Positron Emission Tomography; [18F]FDG; dihydrotetrabenazine; Islet transplantation; IBMIR; beta-cell mass; MEDICINE; MEDICIN;

    Sammanfattning : Type 1 and 2 Diabetes Mellitus are a growing health problem throughout the world. There is an increasing  need for methodologies, which are both reliable and non-invasive to measure the amount of insulin-producing tissue (Beta-cell mass, or BCM), as well as rapidly quantify changes in the BCM due to the onset of disease, beta-cell replacement therapy, or other treatments. LÄS MER