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Visar resultat 1 - 5 av 25 avhandlingar som matchar ovanstående sökkriterier.

1. 1. On the hypersensitivity syndrome induced by the selective serotonin reuptake inhibiting antidepressant Zimeldine : A clinical and experimental study

   Författare :Bengt-O Bengtsson; Linköpings universitet; []
   Nyckelord :Zimeldine; Norzimeldine; Hypersensitivity syndrome; Serotonin reuptake inhibition; Genetic disposition; Lymphocyte transformation test; Experimental allergic neuritis; Immunopharmacology; MEDICINE; MEDICIN;

   Sammanfattning : Zimeldine, the first selective neuronal serotonin (5-H1) reuptake inhibitor to be registered as an antidepressant was withdrawn from common use due to an acute flu-like adverse syndrome comprising fever, myalgia and/or arthralgia and signs of disturbed liver function. A few of these patients also developed a peripheral neuropathy, in the most serious form a Guillain-Barré syndrome (GBS). LÄS MER

3. 2. Irritable Bowel Syndrome : Studies of central pathophysiological mechanisms and effects of treatment

   Författare :Mats Lowén; Susanna Walter; Magnus Ström; Maria Engström; Sigrid Elsenbruch; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Background and aimsIrritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and altered bowel habits. The societal costs of the disorder are significant, as are its negative effects on quality of life. LÄS MER

4. 3. Food Antigen Sensitivity in Coeliac Disease Assessed by the Mucosal Patch Technique

   Författare :Guðjón Kristjánsson; Roger Hällgren; Per Venge; Riccardo Troncone; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Coeliac disease; Diagnostic instrument; food hypersensitivity; gut pathophysiologi; inflammation; nitric oxide; rectal instillation; gluten; corn; milk hypersensitivity; inflammatory bowel disease; irritable bowel syndrome; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Sammanfattning : A diagnosis of coeliac disease (CD) in adults relies on the presence of a structurally abnormal intestinal mucosa, followed by a clear clinical remission on a gluten-free diet. There is a clear need for a rapid, simple, safe and sensitive method to determine the type and intensity of inflammation in the gut mucosa in clinical practice. LÄS MER

5. 4. Peripheral and central factors in the pathophysiology of irritable bowel syndrome

   Författare :Iris Posserud; Göteborgs universitet; []
   Nyckelord :irritable bowel syndrome IBS ; visceral perception; rectal perception; visceral hypersensitivity; gastrointestinal symptoms; hypervigilance; selective attention; stress; small intestinal bacterial overgrowth; rectal barostat; small bowel motility; gastrointestinal dysmotility;

   Sammanfattning : Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by abdominal pain and/or discomfort together with abnormal bowel habits. The pathophysiology is complex and incompletely understood. LÄS MER

7. 5. Irritable bowel syndrome - a disorder of gut-brain interaction

   Författare :Irina Midenfjord; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Irritable Bowel Syndrome; gastrointestinal symptom severity; anxiety; depression; neurophysiological aberrations; psychological alterations; central sensitization;

   Sammanfattning : Irritable bowel syndrome (IBS) is a common and multifactorial functional gastrointestinal (GI) disorder characterized by altered gut-brain communication. Due to the complexity of gut-brain interactions, the aim of this thesis was to enhance the understanding of associations between GI symptom severity and measures from multiple levels along the gut-brain axis in IBS patients. LÄS MER