Sökning: "Human endogenous retrovirus sequences"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Human endogenous retrovirus sequences.
1. Human Endogenous Retroviruses: Studies on Transcriptional Activity and Genetic Variability
Sammanfattning : Endogenous retroviruses (ERVs) are believed to be remains of germ-line infections that have become fixed in the population. They are involved in pathophysiological conditions, in mechanisms leading to infection protection, and directly in the physiology of the organism by participating in the regulation of cellular gene expression. LÄS MER
2. Studies of human endogenous retroviruses and of the TGF-beta signaling pathway
Sammanfattning : The human genome, in common with all mammalian genomes, carries a high load of inheritable retroviral sequences. We have identified and characterized a novel family of these endogenous retroviruses and have named this family HERV-F as based on the primer binding sites of three members. LÄS MER
3. Transcription, splicing and genetic structure within the human endogenous retroviral HERV-H family
Sammanfattning : Human endogenous retroviruses (HERVs) are remains of ancient retroviral infections of the germ line and constitute as much as 3 % of the human genome. HERVs are genetic elements that potentially may provide important biological functions by several different mechanisms. LÄS MER
4. Endogenous Retroviral RNA Expression in Humans
Sammanfattning : Human endogenous retroviruses (HERVs) constitute about 8% of the human genome. There are around 4000 pol-containing retroviral integrations in the human genome, which makes it impractical to measure each of them separately. LÄS MER
5. On the etiology and pathogenesis of systemic lupus erythematosus with special reference to environmental factors
Sammanfattning : Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which environmental factors interact with genetic factors in the development of the disease process and evolution of clinical manifestations. In this thesis both exogenous factors and host factors were investigated, as well as important immunopathological aspects including involvement of immune complex (IC), the complement system and interferon-alpha (IFN-α). LÄS MER