Sökning: "HiF-1"

Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet HiF-1.

1. 1. Skeletal muscle HIF-1 and exercise

   Författare :Helene Rundqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Regular physical activity prevents and improves a number of disease conditions and reduces the risk for premature death substantially. From a clinical as well as a basic science point of view it is important to create a more fundamental understanding of the molecular mechanisms that contribute to the improved functional capacity induced by regular physical activity. LÄS MER

3. 2. A molecular exploration of sensory responses in c. elegans

   Författare :Longjun Pu; Changchun Chen; Simon Tuck; Sara I Wilson; Zhiyong Shao; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; C. elegans; sensation; CRISPR Cas9; G protein-coupled receptors; neuropeptides; acute hypoxia; pathogen; chemosensation; hydrogen sulfide; HIF-1; iron;

   Sammanfattning : Sensation provides a pivotal ability, allowing animals to survive in complex environments. The cues sensed by animals are represented by external stimuli and internal signals. However, the mechanisms mediating sensations in molecular and cellular level are still not well-studied. In this thesis, by using free-living nematodes C. LÄS MER

4. 3. Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium

   Författare :Karolina Helczynska; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Differentiation; Hypoxia; Breast cancer; Breast; HiF-1; HiF-2; 3D-cultures; prognosis;

   Sammanfattning : Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. LÄS MER

5. 4. Transcriptional regulation in neuroblastoma cells under normoxic and hypoxic conditions

   Författare :Annika Jögi; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; cancerology; Cytologi; onkologi; cancer; Cytology; HIF-2; HIF-1; hypoxia; Id; HES-1; bHLH; Neuroblastoma; neuronal differentiation;

   Sammanfattning : The childhood malignancy neuroblastoma develops from early cells of the sympathetic nervous system (SNS), and the tumors often produce catecholamines. Neuroblastoma cells retain several characteristics of immature sympathetic cells including the expression of a number of transcription factors normally expressed during embryogenesis. LÄS MER

7. 5. Identification of novel pathways of regulation of AHR and HIF-­1 function

   Författare :Michael Gralla; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mammalian bHLH-Pas (basic HLH (helix-loop-helix)-PER-ARNT-SIM) proteins belong to the bHLH superfamily of transcription factors. Members of the family have a broad spectrum of functions that among others sense and regulate the cellular response to physiological signals such as low oxygen levels (hypoxia), or environmental signals such as toxins. LÄS MER