Sökning: "Hanjing Xie"

Hittade 1 avhandling innehållade orden Hanjing Xie.

1. 1. Pharmacogenetic and pharmacokinetic studies of cyclophosphamide : in cell, animal and human

   Författare :Hanjing Xie; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cyclophosphamide; Cytochrome P450; Metabolism; Pharmacokinetics; 4Hydroxycyclophosphamide;

   Sammanfattning : Cyclophosphamide (CPA) is widely used anti-cancer drug that has to be catalyzed by the cytochrome P450 (CYP) enzyme 2B6 as well as some other CYPs to exert its cytotoxic activity. A high degree of interindividual variation in CPA kinetics has been reported in both children and adult patients, which may be due to several factors such as concomitantly used drugs, variation in physiological status of individual patients and genetic polymorphism of the CYP enzymes. LÄS MER