Sökning: "HWE reaction"

Hittade 4 avhandlingar innehållade orden HWE reaction.

  1. 1. Synthesis of aromatic bis- and tris(amino acids) and chiral dendrimers

    Författare :Andreas Ritzén; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; HWE reaction; asymmetric hydrogenation; Heck reaction; Amino acids; chiral dendrimers;

    Sammanfattning : A number of protected aromatic bis- and tris(amino acids) have been synthesised by catalytic asymmetric hydrogenation of the corresponding didehydroamino acid derivatives. The didehydroamino acid derivatives were prepared either by a Heck coupling of a 2-amidoacrylate with an aryl dihalide, or by Horner-Wadsworth-Emmons olefination of aromatic aldehydes with phosphonylglycine reagents. LÄS MER

  3. 2. Methods for Asymmetric Olefination Reactions; Development and Application to Natural Product Synthesis

    Författare :Daniel Strand; Tobias Rein; Viresh Rawal; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antitumor agents; Asymmetric Horner-Wadsworth-Emmons; Desymmetrization; Metal-catalyzed olefination; Mucocin; Palladium-catalyzed allylic substitution; Parallel kinetic resolution; Pyranicin; Pyragonicin; Rhenium; Stereoconvergent synthesis; Stereodivergent synthesis; Stereoselective synthesis; Tetrahydropyran; Wittig reaction; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis deals with the development and application of methods for asymmetric olefinations, in particular Horner-Wadsworth-Emmons (HWE) reactions, in the synthesis of certain natural products. Relying on asymmetric HWE reactions to access key building blocks, two natu-ral products, pyranicin and pyragonicin, were synthesized from common late intermediates. LÄS MER

  4. 3. Synthetic studies of marine indole alkaloids and related systems

    Författare :Ann-Louise Jonsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Marine indole alkaloids; antifouling; synthesis; diketopiperazines; HWE-reaction; bis indole alkaloids; imidates; carbazole alkaloids;

    Sammanfattning : This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities. In the first part of this thesis we could establish and confirm the stucture of barettin and 8,9dihydrobarettin, isolated from the marine sponge Geodia baretti. LÄS MER

  5. 4. Novel Organophosphorus Compounds for Materials and Organic Synthesis

    Författare :Keyhan Esfandiarfard; Sascha Ott; Declan Gilheany; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis is devoted to the development of new organophosphorus compounds for potential uses in material science and as reagents in Organic Chemistry. Organophosphorus compounds in a single molecule or organic electronics context are appealing as the phosphorous centers perturb the electronic properties of the π-conjugated systems while at the same time provide synthetic handles for subsequent synthetic modifications. LÄS MER