Sökning: "HMG-CoA reductase"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden HMG-CoA reductase.
1. Pleiotropic effects of HMG-CoA reductase inhibitors : studies in vitro and in vivo
Sammanfattning : Cardiovascular disease (CVD) is the prime cause of death in industrialized countries, resulting from the progression of atherosclerotic lesions. An increased level of plasma cholesterol, particularly within low-density lipoproteins, is a principle risk factor, but also elevated triglycerides and low levels of high-density lipoprotein cholesterol. LÄS MER
2. Adhesive and signaling mechanisms in abdominal sepsis
Sammanfattning : Sepsis is a major cause of mortality in intensive care units despite decades of scientific efforts. The lung is recognized as the most sensitive and critical organ affected by the hyper-inflammatory response in septic patients. Immune cell dysfunction develops in later phases of sepsis making patients susceptible to infections. LÄS MER
3. Body constitution, statin use, and tumor characteristics. Implications for prognosis
Sammanfattning : Breast cancer is an important cause of disease-burden and death in women. To prevent over- and undertreatment of breast cancer patients, new prognostic and predictive factors are needed. LÄS MER
4. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion
Sammanfattning : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. LÄS MER
5. Life Style, Molecular Pathology, and Breast Cancer Risk
Sammanfattning : The breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. LÄS MER