Sökning: "HMG CoA reductase inhibitor"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden HMG CoA reductase inhibitor.

1. 1. Adhesive and signaling mechanisms in abdominal sepsis

   Författare :Su Zhang; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; abdominal sepsis; lung; infection; neutrophil; chemokines; T-cells; HMG-CoA reductase; NFAT;

   Sammanfattning : Sepsis is a major cause of mortality in intensive care units despite decades of scientific efforts. The lung is recognized as the most sensitive and critical organ affected by the hyper-inflammatory response in septic patients. Immune cell dysfunction develops in later phases of sepsis making patients susceptible to infections. LÄS MER

3. 2. Serum lipoprotein(a) in relation to ischemic heart disease and associated risk factors

   Författare :Lisbeth Slunga; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein a ; lipids; epidemiology; coronary artery disease; coronary angiography; HLA DR; acute-phase protein; myocardial infarction; HMG CoA reductase inhibitor; simvastatin;

   Sammanfattning : Lipoprotein(a) (Lp(a)) consists of an LDL-like particle and the specific protein apo(a), which is very similar to plasminogen. Apo(a) contains repeated kringle structures and a serine protease domain, which cannot be activated by t-PA. Lp(a) is considered to be a predictor for atherosclerotic disease. LÄS MER

4. 3. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

   Författare :Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

   Sammanfattning : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. LÄS MER

5. 4. Studies on N-linked glycosylation in proliferation and viability of normal and tumor cells in vitro

   Författare :Magdalena Carlberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Apoptosis; DNA synthesis; IGF-1 receptor; HMG-CoA reductase; lovastatin; mevalonate; N-linked glycosylation; PDGF; SV40-transformation; tumor; tunicamycin.;

   Sammanfattning : A number of studies suggest a critical role of N-linked glycosylation for cellular proliferation. In addition, many transformed and tumor cells have an altered 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and an increased N-linked glycosylation. LÄS MER

7. 5. On the regulation of hepatic cholesterol and bile acid metabolism in gallstone patients

   Författare :Carl-Gustaf Hillebrant; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Bile acid synthesis; biliary lipids; cholesterol synthesis; cholesterol 7a-hydroxylase; cholesterol synthesis inhibitor; chenodeoxycholic acid; cholestyramine; 7a-hydroxy-4-cholesten-3-one; HMG CoA reductase; lathosterol; lipoproteins; lithocholic acid; plasma apheresis; ursodeoxycholic acid;

   Sammanfattning : The liver plays an important role in the regulation of cholesterol homeostasis, therefore also in the pathogenesis of arteriosclerosis and gallstone disease. The quantitatively most important way by which cholesterol is removed from the human body is via the bile, either as free cholesterol or after transformation to bile acids. LÄS MER