Sökning: "HLA-DQ"
Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet HLA-DQ.
1. Childhood Thyroid and Islet Autoimmunity. Immunogenetics, Risk Factors and Prediction
Sammanfattning : .... LÄS MER
2. The importance of immunological, genetic and clinical factors for beta cell function in childhood diabetes
Sammanfattning : Type I diabetes is caused by environmentally initiated, progressive autoimmune destruction of pancreatic beta cells in genetically susceptible individuals, which results in insulin deficiency and hyperglycemia. At diagnosis, about 10-20 % of beta cells remain, but after insulin therapy is started, a period with regained secretive capacity follows. LÄS MER
3. Novel cardiovascular risk factors in childhood
Sammanfattning : Individuals with type 1 diabetes (T1D) have a 2 to 3-fold increased risk for cardiovascular disease compared to non-diabetic subjects. Exposure to a broad panel of risk factors in childhood may cause vascular damage with potentially long-term consequences for cardiovascular morbidity. LÄS MER
4. Molecular mechanisms of HLA associations with myasthenia gravis
Sammanfattning : Myasthenia gravis (MG) is a neuromuscular disease characterised by muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR). MG has a complex pattern of inheritance and several genetic and environmental factors are important in conferring susceptibility to the disease. LÄS MER
5. Immunogenetics of Childhood Type 1 Diabetes in Immigrant Patients in Sweden. Migration Studies on Type 1 Diabetes
Sammanfattning : This thesis examined whether the offspring of immigrants (non-Swedes) to Sweden are at increased risk of Type 1 Diabetes (T1D) when they are born or live in Sweden. It also evaluated if their T1D and T2D-related genes differed from Swedish patients and whether this genetic heritage determined the types and existence of islet autoantibodies at time of diagnosis and affected the classification of diabetes. LÄS MER