Sökning: "HLA DR4"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden HLA DR4.

  1. 1. Genetic markers in rheumatoid arthritis

    Författare :Solbritt Rantapää Dahlqvist; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; family history; genetic marker; HLA B27; HLA DR4; properdin factor B; C3 complement; -antitrypsin; haptoglobin; transferrin;

    Sammanfattning : Genetic as well as environmental factors are believed to be of importance in the etiology of rheumatoid arthritis (RA). There are a number of previous studies of genetic markers in RA, but so far no genetic linkage and only a few associations have been found. Of the associations only one (with the HLA antigen DR4) appears to be well documented. LÄS MER

  3. 2. Serologic Markers in Screening for Coeliac Disease, Clinical significance and immunogenetic basis

    Författare :Klas Sjöberg; Gastroenterologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastro-enterology; transglutaminase; specificity; sensitivity; prevalence; HLA; liver disease; endomysial antibodies; gliadin antibodies; diabetes; Autoimmune disease; coeliac disease; Gastroenterologi;

    Sammanfattning : The prevalence of coeliac disease (CD) was initially estimated to 1/1537. Based on serial analysis [GA and endomysial antibodies (EMA)], the prevalence was 6/1970 (0.30%). In autoimmune chronic hepatitis 5. LÄS MER

  4. 3. Cartilage proteins and their arthritogenic properties in arthritis

    Författare :Stefan Carlsén; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; HLA-DR4; tolerance; COMP; CXI; CIX; arthritis; Cartilage; collagen;

    Sammanfattning : In this thesis the role of cartilage proteins and their potential as antigen and availability to the immune system in arthritis were investigated. Six papers are included; where four present new animal models for Rheumatoid arthritis (RA), one shows how genetic disorders in cartilage may affect arthritis and the last how posttranslational modification of collagen type II (CII) affects tolerance. LÄS MER

  5. 4. Population-based analysis of the HLA associated risk for IDDM

    Författare :Ingrid Kockum; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin-dependent diabetes mellitus; HLA-DR; HLA-DQAl; HLA-DQBl; predispositional allele test; absolute risk; relative predispositional effect; transmission rates; non-inherited maternal haplotypes.;

    Sammanfattning : Insulin dependent diabetes (IDDM) is one of the most common chronic illnesses among children and young adults in Sweden. The disease has a complex pattern of inheritance and environmental factors are important. The strongest linkage to IDDM is found on chromosome 6p21 in the Major Histocompatibility Complex (MHC) region. LÄS MER

  7. 5. HLA, salivary IgA and mutans streptococci - is there a relation?

    Författare :Marie Louise Wallengren; Malmö högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunoglobulin A; Streptococcus mutans; Streptokocker; Karies;

    Sammanfattning : Mutansstreptokocker (MS) är en grupp bakterier som i många studier visats ha ett starkt samband med karies. Bakterierna anses tillhöra vår normala munflora, men alla individer har inte MS och mängden skiljer sig mycket från en individ till en annan. Orsakerna till denna variation är till viss del välkända, som t.ex. LÄS MER