Sökning: "Genetic disposition"

Visar resultat 11 - 15 av 23 avhandlingar innehållade orden Genetic disposition.

  1. 11. Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

    Författare :Anders H Olsson; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Genetics; Epigenetics; Human Pancreatic Islets; Oxidative Phosphorylation; Insulin Secretion;

    Sammanfattning : The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. LÄS MER

  3. 12. Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism

    Författare :Magnus Christensen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; phenotype; CYP1A2; caffeine; melatonin; fluvoxamine; omeprazole; losartan; debrisoquine; quinine; genotype; single nucleotide polymorphism;

    Sammanfattning : Assessment of the cytochrome (CYP) P450 enzyme activity or phenotyping is a method to characterise the real activity of an enzyme by the use of a marker probe drug. The information of the phenotype is of clinical relevance because it reflects the combined effects of genetic, environmental e.g. LÄS MER

  4. 13. Interindividual Variability of Drug Transport Proteins : Focus on Intestinal Pgp (ABCB1) and BCRP (ABCG2)

    Författare :Gunilla Englund; Per Artursson; Håkan Melhus; Andreas Kindmark; Joseph W Polli; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; membrane transport proteins; ATP-Binding Cassette Transporters; P-glycoprotein; Breast Cancer Resistance Protein; Interindividual variability; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : The appearance of adverse drug reactions is a common reason for hospitalization in Western countries. Research on underlying biological mechanisms for interindividual variability in drug response aims to better identify patients with exceptional genetic traits, disease conditions or risk of drug-drug interactions and thereby help to prevent adverse drug reactions. LÄS MER

  5. 14. Ancient DNA as a Means to Investigate the European Neolithic

    Författare :Helena Malmström; Anders Göterström; Gunilla Holmlund; T Brown; Uppsala universitet; []
    Nyckelord :Molecular genetics; aDNA; contamination; authentication; mtDNA; Neolithisation; Genetik;

    Sammanfattning : The transition from a hunter-gatherer lifestyle to a farming lifestyle, i.e. the Neolithisation, is arguably the most important event in human prehistory. While the geography and dating of the Neolithisation is well known, the process is still under debate, especially if it occurred through diffusion of ideas or with migrating farmers. LÄS MER

  7. 15. Pharmacogenetic aspects of HIV/AIDS, tuberculosis and malaria : emphasis on Ugandan population

    Författare :Jackson Kijumba B Mukonzo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Infectious diseases such as HIV, tuberculosis and malaria are endemic in Africa and often require concomitant treatments that may result into subsequent drug–drug interactions. Inter-individual variability in the pharmacokinetics and pharmacodynamics of drugs used in infectious diseases, as a result of genetic polymorphism, has been reported. LÄS MER