Sökning: "GLYCANS"

Visar resultat 1 - 5 av 90 avhandlingar innehållade ordet GLYCANS.

  1. 1. The sweet side of molecular structure : NMR spectroscopic studies of glycans and their interactions with proteins

    Författare :Christoffer Hamark; Göran Widmalm; Mario Schubert; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioorganic chemistry; glycans; ligand-based NMR; molecular simulations; protein-carbohydrate interactions; lectins; carbohydrate conformations; 77Se NMR; structure-reactivity relationships; super-armed donors; organisk kemi; Organic Chemistry;

    Sammanfattning : In this thesis, within the topic of bioorganic chemistry, the molecular structure of carbohydrates has been studied. Carbohydrates, or glycans, are ubiquitous biomolecules exhibiting a wide range of biological roles. LÄS MER

  3. 2. Tales from the Sweet Side of Life : Structure and dynamics of carbohydrate-based systems

    Författare :Alessandro Ruda; Göran Widmalm; Jesús Jiménez Barbero; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbohydrates; nuclear magnetic resonance; molecular dynamics; glycans; conformational analysis; structure elucidation; protein-glycan interactions; Organic Chemistry; organisk kemi;

    Sammanfattning : The field of glycomics has experienced significant developments in the last few decades, revealing a profound and elaborate language behind the intrinsic complexity of the glycans structures. This ‘sugar code’ is at the basis of intercellular interaction and recognition. For this language to be understood, its chemical basis must be unveiled. LÄS MER

  4. 3. Structural studies of glycans by NMR spectroscopy

    Författare :Carolina Fontana; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  5. 4. Herpesvirus-induced expression of sLe(x) and related O-linked glycans in the infected cell

    Författare :Kristina Nyström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HSV-1; CMV; VZV; O-linked glycans; Lewis antigens; ICP0;

    Sammanfattning : Lewis antigens constitute a family of fucosylated carbohydrate antigens (glycotopes), involved in leukocyte homing and related immunological phenomena. These glycotopes are only expressed restrictedly in normal cells, but are induced at appropriate occasions. It is well established that many tumors ?hijack? Lewis glycotopes for e.g. LÄS MER

  7. 5. Recombinant mucin-type proteins as tools for studies on the interactions between Helicobacter pylori and its carbohydrate receptors

    Författare :Yolanda H. Mthembu; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; O-glycans; mucins; glycosyltransferases; Helicobacter pylori; microbial adhesion;

    Sammanfattning : Glycan-protein interactions are important in pathogen adhesion and infections. H. pylori has adhesins which enables it to bind to glycans on the gastric mucosa and, in the long run, cause gastric cancer. The reported current antibiotic regimen used in the treatment to eradicate H. LÄS MER