Sökning: "Fluconazole"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet Fluconazole.

  1. 1. Development and validation of a localized murine candidiasis model : The pathogenesis, chemotheraphy and defense mechanisms to Candida mastitis in the lactating mouse

    Författare :Faisal Abdi Guhad; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Murine model; Candida albicans; Pathogenesis; Virulence factors; Amphotericin B; Fluconazole; Complement activation; C3c; SCID mice; Nude mice; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : A murine model of localized candidiasis (mastitis) was developed. The model was analyzed withrespect to its discriminative abilities through investigation of the virulence properties of C.albicans mutant strains compared with the wild-type parental strain. LÄS MER

  3. 2. Studies on laboratory diagnosis of fungal infection and antifungal susceptibility

    Författare :Erja Chryssanthou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Invasive fungal infections (IFI) are serious complications in immunocompromised hosts. Neutropenic patients with haematological malignancies or after transplantation are at risk of developing deep Candida or Aspergillus infections. LÄS MER

  4. 3. Innate immune factors in recurrent and persistent infections of the lower female genital tract

    Författare :Cathrin Alvendal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :C. albicans;

    Sammanfattning : Background: Infections of the female genital tract are common and have severe impact on the quality of life and sexual health of affected women. The innate immune system is crucial and is involved in the defense of infections. LÄS MER

  5. 4. Infections in patients with haematological malignancies

    Författare :Honar Cherif; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Haematological malignancies; febrile neutropenia; bacteraemia; Candida; oral antibiotic; risk stratification; FUO; cefepime; splenectomy; pneumococcal vaccine;

    Sammanfattning : Infectious complications are an important cause of morbidity and mortality in patients with hematological diseases, especially during chemotherapy induced neutropenia. This study was undertaken with the ultimate goal to improve the clinical management of infections in patients with hematological diseases. LÄS MER

  7. 5. CYP2C19 and CYP2C9 geno- and phenotypes in healthy Swedish and Korean subjects

    Författare :Margareta Ramsjö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to affect the individual drug response. CYP2C19 and CYP2C9 are both polymorphic enzymes and are responsible for the metabolism of many therapeutically used drugs, e.g. LÄS MER