Sökning: "Flinders sensitive line"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Flinders sensitive line.
1. On the importance of inflammation for personality traits and psychiatric morbidity
Sammanfattning : Background: Pro-inflammatory mediators have been implicated in processes that could be both beneficial and toxic to cells in the brain. On the one hand balanced levels of these mediators favour e.g. LÄS MER
2. On Neuroimmunology and Brain Function: Experimental and Clinical Studies
Sammanfattning : The immune system has been implicated in the mechanisms underlying many psychiatric disorders. Immune mediators are expressed in the central nervous system (CNS) not only in response to harmful stimuli, but also in a constitutive manner, and serve as important plasticity factors during development. LÄS MER
3. On antidepressant effects of running and SSRI : focus on hippocampus and striatal dopamine pathways
Sammanfattning : Considering the heterogeneous character of depression, it seems likely that many brain regions are involved mediating the diverse symptoms of depression. For example, the mesolimbic DA system has a central function for motivational behaviors and pleasure seeking, and it is possible that malfunctioning of brain reward systems could be an underlying mechanism of the anhedonia experienced in depressive illness. LÄS MER
4. Imbalanced kynurenine pathway in schizophrenia and depression : immunological and genetic aspects
Sammanfattning : Kynurenic acid (KYNA), an end metabolite of the kynurenine pathway along tryptophan degradation, has gained increasing interest in the pathophysiology of psychiatric disorders. Elevated levels of KYNA have been found in the cerebrospinal fluid (CSF) and in the postmortem brain of patients with schizophrenia and bipolar disorder with psychotic symptoms. LÄS MER
5. Antidepressive and antipsychotic treatments : effects on nerve growth factor and brain-derived neurotrophic factor in rat brain
Sammanfattning : Recently it has been reported that depression and schizophrenia, the two major psychiatric disorders, are characterized by loss of neurons in specific brain regions. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are proteins involved in neuronal survival and plasticity of dopaminergic, cholinergic and serotonergic neurons in the central nervous system (CNS). LÄS MER