Sökning: "FcεRI"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet FcεRI.

  1. 1. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation

    Författare :Jessica Alfredsson; Gunnar Nilsson; Hans-Uwe Simon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; SCF; IL-3; FcεRI; migration; apoptosis; Bim; Bcl-2; Bcl-XL; Akt; FOXO; MAPK; Patologi; Pathology; Patologi;

    Sammanfattning : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. LÄS MER

  3. 2. Charting mast cell development in health and systemic mastocytosis

    Författare :Chenyan Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hematopoietic stem and progenitor cells give rise to various blood and immune cells, including mast cells. In adults, bone marrow hematopoietic stem cells give rise to mast cell progenitors. These mast cell progenitors circulate in the peripheral blood and mature in peripheral tissues. LÄS MER

  4. 3. Why Is It So Hard to Kill a Mast Cell?A Study of Mast Cell Activation and Survival

    Författare :Xiang Zou; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; A1; allergy; apoptosis; Bfl-1; degranulation; FcepsilonRI; IgE; inflammation; mast cells; nerve growth factor; regranulation; TrkA; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Mast cells have a long life in tissues, where they are involved in inflammatory and hypersensitivity reactions. Activation through cross-linking of the high-affinity IgE-receptor (FcεRI) is a primary stimulus capable of degranulating mast cells, contributing to symptoms of allergy. LÄS MER

  5. 4. Mast cell development in health and systemic mastocytosis

    Författare :Jennine Grootens; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hematopoietic progenitors in the bone marrow differentiate into several immune cells, including mast cells. Mast cell progenitors leave the bone marrow, circulate through the blood, and home to the periphery where they mature. LÄS MER

  7. 5. New aspects of tissue mast cells in inflammatory airway diseases

    Författare :Cecilia Andersson; Luftvägsinflammation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Mast cell are found throughout the body, but are especially prominent in tissues that have direct contact with the external milieu such as the skin, gastrointestinal tract and lungs. Mast cells are commonly recognized for their detrimental role in allergic reactions and can, upon activation through the high-affinity receptor for IgE (FcεRI), rapidly produce and secrete many of the mediators responsible for the typical symptoms in urticaria, asthma and rhinitis. LÄS MER