Sökning: "FcγR"
Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet FcγR.
1. A Search for the Masked Mechanism Behind IgG-Mediated Suppression of Antibody Responses
Sammanfattning : Antibodies passively administered together with their specific antigen can enhance or suppress the specific antibody response. This phenomenon is known as antibody feedback regulation. Whether this modulation causes up- or downregulation of the antibody response depends both on the antibody isotype and the antigen used. LÄS MER
2. The Role of Fc gamma Receptors and Mast Cell Chymase in Autoimmune Arthritis
Sammanfattning : In autoimmune diseases such as rheumatoid arthritis (RA), self-reactive antibodies are present at high levels, which contributes to disease pathogenesis. The antibodies mediate their effect predominantly by binding to Fc gamma receptors (FcγR) on various leukocytes, such as monocytes, macrophages and mast cells, where FcγR ligation leads to cell activation. LÄS MER
3. Signal transduction in human phagocytic cells during phagocytosis, oxidative activation and apoptosis
Sammanfattning : Neutrophils and macrophages are professional phagocytic cells that play a crucial role in host defense against invading microorganisms. They bind to, internalize, and subsequently kill microbes with an arsenal of reactive oxygen metabolites and microbicidal agents. LÄS MER
4. Fc receptors and immunoglobulins in polyarthritis : A matter of function, supply and demand?
Sammanfattning : Fc receptors (FcR) and immunoglobulins (Ig) play important roles in the defence against pathogens. However, altered interactions of these may promote chronic inflammation in rheumatic diseases. An excess of Igs forming immune complexes (IC) could lead to continuous FcR activation and spreading of autoimmune inflammation to other tissues. LÄS MER
5. Genetic regulation of autoantibodies in arthritis : lessons from mouse models
Sammanfattning : Autoimmune diseases such as rheumatoid arthritis (RA) or multiple sclerosis (MS) are commonly regarded as complex or multifactorial diseases. This complexity regards to effector mechanisms involved in pathologic manifestations, and also to the diversity of genetic and environmental factors that predispose individuals to such diseases. LÄS MER