Sökning: "Family-based association test"

Hittade 5 avhandlingar innehållade orden Family-based association test.

  1. 1. Statistical methodology for testing genetic association in family-based studies

    Författare :Gudrun Jonasdottir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis is concerned with family-based studies of association between genetic markers and binary traits. A special point of interest in family-based association studies is to separate the within family correlation and the genetic effect common among all families in the study. LÄS MER

  3. 2. The Genetics of Systemic Lupus Erythematosus : The Specificity of IRF5 to SLE

    Författare :MV Prasad Linga Reddy; Marta Alarcön Riquelme; Dan Holmberg; Uppsala universitet; []
    Nyckelord :Molecular genetics; Systemic lupus erythematosus; Interferon regulatory factor 5; Transmission-Disequilibrium Test; Family-based association test; Linkage Disequilibrium; Hardy-Weinberg equilibrium; Genetik;

    Sammanfattning : The breakdown of self-tolerance is the main driving force behind susceptibility to SLE. When this occurs, T and B cells are activated in an uncontrolled manner and produce autoantibodies against self fragmented DNA, RNA and sometimes other parts of the cell such as cardiolipin, phosphatidylserine, etc. LÄS MER

  4. 3. Genetics of type 2 diabetes and the metabolic syndrome

    Författare :Mia Klannemark; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; PDE3B; PPARG; LPL; metabolic syndrome; diabetes; genetic; HSL; UCP2; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Type 2 diabetes and the metabolic syndrome are highly prevalent disorders with severe complications such as cardiovascular disease. The aetiology of type 2 diabetes and the metabolic syndrome is not known, but the interaction between genetic factors and environmental triggers is important. LÄS MER

  5. 4. Socioeconomic influences on late-life health and mortality : exploring genetic and environmental interplay

    Författare :Malin Ericsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The objective of this thesis was to increase the understanding of socioeconomic differences in health and mortality in old age - in a genetically informative setting. Data from the Swedish Twin Registry (STR), different statistical methods, and family-based designs were applied to investigate socioeconomic circumstances over the life-course and how these affect cognitive function, frailty, and mortality in late life. LÄS MER

  7. 5. Reading achievement : Its relation to home literacy, self-regulation, academic self-concept, and goal orientation in children and adolescents

    Författare :Lena Swalander; Institutionen för psykologi; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Psychopedagogy; Psychology; Writing; Computers; Home literacy; Reading attitude; Goal orientation; Reading ability; Academic self-concept; Self-regulated learning; Pedagogisk psykologi; Psykologi;

    Sammanfattning : The studies in this doctoral thesis investigated how home literacy, self regulation, academic self-concept, and goal orientation influence reading ability. Study 1 investigated the effect of family-based prerequisites, reading attitude, and self-regulated learning on reading ability. LÄS MER