Sökning: "False positive signals"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden False positive signals.
1. Track circuits’ robustness : Modeling, measurement and simulation
Sammanfattning : In countries with rough weather conditions, frequent delays cause railway companies to waste time and money. Many of these delays are related to the train detection systems, as the old DC track circuits are still used in some countries, including Sweden, our case study. LÄS MER
2. Aβ Conformation Dependent Antibodies and Alzheimer's Disease
Sammanfattning : Soluble intermediates of the amyloid-β (Aβ) aggregation process are suggested to play a central role in the pathogenesis of Alzheimer’s disease (AD) by causing synaptic dysfunction and neuronal loss. In this thesis, soluble Aβ aggregates have been studied with a particular focus on the Aβ protofibril, which has served as the antigen for developing conformation dependent monoclonal antibodies. LÄS MER
3. Selectivity in NMR and LC-MS Metabolomics : The Importance of Sample Preparation and Separation, and how to Measure Selectivity in LC-MS Metabolomics
Sammanfattning : Until now, most metabolomics protocols have been optimized towards high sample throughput and high metabolite coverage, parameters considered to be highly important for identifying influenced biological pathways and to generate as many potential biomarkers as possible. From an analytical point of view this can be troubling, as neither sample throughput nor the number of signals relates to actual quality of the detected signals/metabolites. LÄS MER
4. Novel methods for improving rapid paper-based protein assays with gold nanoparticle detection
Sammanfattning : This thesis describes methods for improving sensitivity in rapid singleplex and multiplex microarray assays. The assays utilize the optical characteristics of colloidal gold nanoparticles for the colorimetric detection of proteins.Multiplexed detection in sandwich immunoassays is limited by cross-reactivity between different detection antibodies. LÄS MER
5. Robust inference of gene regulatory networks : System properties, variable selection, subnetworks, and design of experiments
Sammanfattning : In this thesis, inference of biological networks from in vivo data generated by perturbation experiments is considered, i.e. deduction of causal interactions that exist among the observed variables. Knowledge of such regulatory influences is essential in biology. LÄS MER