Sökning: "FTO"

Visar resultat 1 - 5 av 24 avhandlingar innehållade ordet FTO.

  1. 1. Obesity and Increased Susceptibility : Role of FTO and MGAT1 Genetic Variants

    Författare :Josefin A Jacobsson; Robert Fredriksson; Helgi B Schiöth; Sadaf Farooqi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; BMI; SNP; haplotype; association study; FTO; MGAT1; Pharmacology; Farmakologi; Farmakologi; Pharmacology;

    Sammanfattning : Obesity is a complex and a highly individualized disease and the molecular mechanisms behind this disorder need to be better elucidated. Identification of genes and genetic variants that are involved provide opportunities to establish a genetic understanding of the disease. LÄS MER

  3. 2. Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies

    Författare :Jaana Gustavsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Coronary heart disease; gene-lifestyle interaction; APOE; FTO; GHRL; smoking; physical activity; diet; obesity;

    Sammanfattning : Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on apolipoprotein E (APOE), fat mass and obesity-related (FTO) and ghrelin/obestatin prepropeptide (GHRL) genes, as well as smoking, physical activity and diet. LÄS MER

  4. 3. Bone health and nutrition treatment. Studies on young women with anorexia nervosa and children with epilepsy

    Författare :Anna Svedlund; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intensive nutrition treatment; modified Atkins diet; vitamin D; FTO; bone mass; bone biomarkers; growth; skeleton; anorexia nervosa; eating disorder;

    Sammanfattning : Background: Adequate nutritional status is crucial for optimal longitudinal growth and accrual of bone mass during childhood and adolescence. Peak bone mass achieved in young adulthood affects bone health throughout life. LÄS MER

  5. 4. The role of genetics in regulation of weight loss and food intake

    Författare :Marcus Bandstein; Helgi Schiöth; Jarl Torgerson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FTO; RYGB; LYPLAL1; TFEQ; Genetic Risk Score; methylation; food intake; Bioinformatics; Bioinformatik; Medicinsk genetik; Medical Genetics;

    Sammanfattning : While obesity is a world leading health problem, the most efficient treatment option for severely obese patients is Roux-Y gastric bypass (RYGB) surgery. However, there are large inter-individual differences in weight loss after RYGB surgery. LÄS MER

  7. 5. Gene x lifestyle interactions in type 2 diabetes mellitus and related traits

    Författare :Ema C Brito; Paul Franks; Aline Meirhaeghe; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene x environment interaction; gene x lifestyle interaction; physical activity; type 2 diabetes; European Youth Heart Study; Malmö Preventive Project; Prevalence and Prediction and Prevention of Diabetes in Botnia; PPARGC1A; CDKN2A B; HNF1B; TCF7L2; FTO; Epidemiology; Epidemiologi; epidemiologi; Epidemiology; genetik; Genetics;

    Sammanfattning :   Background: Type 2 diabetes is thought to result from interactions between genetic and lifestyle factors, but few robust examples exist. The overarching aim of this thesis was to discover such interactions by studying cohorts of white youth and adults from northern Europe in which physical activity, genotypes, and diabetes-related traits or diabetes incidence had been ascertained. LÄS MER