Sökning: "FOXO"
Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet FOXO.
1. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation
Sammanfattning : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. LÄS MER
2. Skeletal muscle plasticity and energy metabolism
Sammanfattning : Skeletal muscle is remarkable in its ability to adjust to our needs. It can change its energy stores and usage, as well as its total mass. Furthermore, skeletal muscle adapts to deactivate reactive oxygen species produced, which in turn can both damage cells and convey signals. LÄS MER
3. Smoking and T cell co-stimulation in rheumatoid arthritis
Sammanfattning : In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. LÄS MER
4. Gene regulation in normal and malignant B-lineage cells
Sammanfattning : B-cells are the central players of humoral immunity. It is known that their development is orchestrated by a small group of transcription factors including the E-proteins and the FOXO proteins, yet this process is far from completely understood. LÄS MER
5. Discovering and targeting the mechanisms that govern age-related decline
Sammanfattning : Aging is recognized as a major risk factor for many diseases. Thus, the identification of a means to target aging would bear great potential to improve human health and quality of life. LÄS MER